Clinical efficacy of melatonin for prevention of common migraine headache in comparison with propranolol
karbala journal of pharmaceutical sciences,
Volume 5, Issue 7, Pages 131-139
AbstractMigraine is a common primary headache disorder with a wide spread mechanisms that explain it’s pathologyphysiological and there is no exact single theory that can determine the etiology of this disorder .The successful abortive treatment is obscure tell now a day, indicating prophylactic measures to decrease frequency , severity and duration of headache attacks. Propranolol is one of FDA approved drugs for the common migraine prevention where its chronic therapy reduces the frequency and severity of migraine in 60 to 80 percent of patients . Melatonin a pineal gland hormone that has ability for circadian rhythm control and was linked to migraine several ways. Both episodic (55%) and chronic (62.5%) migraineours reported waking up in the morning with headaches or being woken up at night by the headache . In addition, headaches occurring in the morning period have been attributed to sleep disorders. The present study was carried out to determine the efficacy of melatonin 5 mg daily for prevention of common migraine in comparison with propranolol 40 mg twice daily for 41 patient having for full criteria of common migraine headache with assessment of AST , ALT, Scr for all patients to ensure the safety of investigated drugs .The study concluded that melatonin has no significant difference than that of propranolol efficacy in the common migraine prevention and approved safety .
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