Role of Fucus vesiculosus L extract in the regulation of thyroid hormones status in adult male rabbits
karbala journal of pharmaceutical sciences,
Volume 5, Issue 7, Pages 67-84
AbstractBackground: The thyroid hormones triiodothyronine (T3 ) and thyroxine (T4 ) are formed in a large prohormone molecule. The formation of this hormones depends on an exogenous supply of iodide. So that normal thyroid hormone synthesis requires iodide, Fucus vesiculosus (also known by the common name bladder wrack ) is a marine algae rich in iodine, which is being used in alternative medicine as a complement (for weight loss and as source of iodine) and in treatment of thyroid disorders, particularly hypothyroidism.
Aim: Evaluation the use of Fucus vesiculosus in alternative medicine as complement and regulator for the thyroid hormones.
Methods: This study presents the effects of aqueous extract and isolated flavonoids from Fucus vesiculosus L algae to the level of thyroid-stimulating hormone-TSH, T3,T4, antioxidant parameters:glutathione-GSH, glutathione peroxidase-GPx, peroxynitrite and malondialdehyde-MDA in sera of 35 adult male rabbits divided randomly into seven groups (5 animals in each group), in which G1, G2 and G3 treated with (25,50and75) mg/kg/day of aqueous extract of algae respectively, while the G4, G5 and G6 were treated with (25,50and75)mg/kg/day of isolated flavonoids,compared with non-treated as control group.
Results: The results indicate that the level of TSH was significantly decreased (p≤0.05) in sera of rabbits in G3 G4, G5 and G6 with no significant change in G1 and G2 as compared with control, while the level of T4 were significantly decreased (p≤0.05) in sera of all six groups G1, G2, G3, G4, G5 and G6 as compared with control. The levels of T3 show significantly increased (p≤0.01) in sera of G1, G2 G4 and G6 with no significant change in G3 as compared with control, the levels of GSH were significantly decreased (p≤0.05) in sera of G1 ,G2, G4, G5 and G6 with no significant change in G3 as compared with control. Otherwise the levels of GPx were significantly increased (p≤0.05) in sera of G2 and G6, and decreased in G5 with no significant change in G1,G3 and G4 as compared with control, while the levels of peroxynitrate were significantly decreased (p≤0.05) in sera of G1,G3, G4, G5 and G6 and significantly increased (p≤0.05) in G2 as compared with control, while the levels of MDA were significantly increased (p≤0.05) in sera of G2,G3, G5 and G6 as compared with control.
Histological examination of thyroid gland sections from different treated groups showed considerable changes as compared with non-treated as control group, the aqueous extract from algae administration stimulates hyperactivity of thyroid gland in all three groups (G1, G2 and G3). Thyroid follicles became larger, containing dense colloidal. Connective tissues in between thyroid follicles along with blood vessels can be observed, with presence of many profollicular cells in groups treated with isolated flavonoids G4,G5,G6, and the ideal structure of thyroid follicles and moderate colloid material within follicles .
Conclusion: From all the above results we can conclude that the use of algae extracts with suitable antioxidant such as Vit. C (to reduce the oxidative stress) may regulate the thyroid hormones levels and improved the function of thyroid gland in sera of hypothyroidism animals.
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