Biochemical studies of thyrotrophin,L-fucose,cathepsin B and some parameters in blood serum of patients suffering from breast tumour
karbala journal of pharmaceutical sciences,
Volume 4, Issue 6, Pages 47-57
AbstractA developed methed was established to 70 patients suffering from breast tumour(negative axilliary node) from kirkuk city to determine the level of total fucose (TF),protein bound fucose (PBF),iron(Fe),total iron binding capacity(TIBC),unsatuted iron binding capacity(UIBC),transferrien,transferrien saturation,alkalin Phosphate(ALP),total protein(TP),albumin(ALB),glubuline(GLUB). The study also determines the level of thyrotropin (TSH),cathepsin B ,cholestol(CH),high density Lipoprotein cholestol (HDL-c),low density lipoprotein(LDL) in sera of three groups(benign, pre-post menopausal malignant of breast tumour. The results obtained showed highly significant increase in the level of TF,PBF, ALP,TP,GLUB,TIBC,and for(15-25),(36-45)age group for Fe and transferrien saturation,while there are highly significant decrease in UIBC,TIBC,Transferrien,ALB concentration in sera of breast tumour patients compared with control group. The results obtained about TSH,cathepsin B showed that there is significant decrease in sera of women affected by benign tumour and significant increase in sera of premenopausal breast tumour ,while in postmenopausal breast there is more significant increase of cathepsin B and more significant decrease of TSH,and also there is elevation in CH,LDL, and decrease in HDL-c for benign to pre to Postmenopausal breast tumour.
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