Synthesis and study the Biological Activity of some new bis Maleimide derivatives containing 1 ,3 ,4- Oxadiazole ring
karbala journal of pharmaceutical sciences,
2013, Volume 4, Issue 5, Pages 149-169
AbstractThis paper contains the synthesis of some new bis heterocyclic compounds starting from the esters of bis carboxylic acid which then converted to its hydrazide [1-5] then to bis1,3,4-Oxadiazole derivatives [6-10] beside bis maleamic acid derivatives [11-15] and finally with bis maleimides [16-20] .
Preparing of bis ester by usual esterification of substituted bis aliphatic carboxylic acid with absolute ethanol in acidic medium , then has converted to its substituted bis aliphatic carboxylic acid hydrazide by reacting it with hydrazine hydrate . The derivatives bis-1,3,4-Oxadiazole have synthesized by cyclization of bis aliphatic carboxylic acid hydrazide with 4- amino benzoic acid in presence of phosphoric acid 85% .
So ,the bis- maleamic acids have been synthesized by the reaction of compounds [6-10] with maleic anhydride in diethyl ether. Also bis maleimides are synthesized by cyclization of bis maleamic acids derivatives by using acetic acid anhydride and anhydrous sodium acetate. The synthesized compounds were identified by spectral methods UV,FT-IR and H1- NMR beside melting point and the purity was determined by using ( TLC ) and some of its physical properties were measured . Some of these compounds are tested against four strains of bacteria ( Staph. aurease , E. coli ,Sal. thph and Ps. aeruginosa)
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