Synthesis, Characterization and study of antibacterial activity in vitro of some hydrazones and formazan dyes containing benzothiazole moiety
karbala journal of pharmaceutical sciences,
2013, Volume 4, Issue 5, Pages 81-90
Abstract2-mercaptobenzothiazole (I) on treatment with hydrazine hydrate and HCl by two methods, µW and direct heating with solvent, give 2- hydrazinobenzothiazole (II), which on condensation by µW and direct heating with substituted aromatic aldehydes affords aryl substituted (1,3-benzothiazole-2-yl)hydrazone (III). The latter on treatment with aryl diazonium chloride at low temperature degree furnishes respective 1-(benzothiazol-2-yl)-5-(4-sub.phenyl)-3-arylformazan(IVa-e,Va-e,VIa-e)(formazan dyes) which on have been used as pigments for cotton, wool and white wood, and showed a significant value and also showed a resistance for primary washing process.
The antibacterial activities of these compounds have been assayed against various Gram -ve and Gram +ve organisms. The structures were elucidated and spectral behaviors were investigated with the use of 1HNMR, 13CNMR, FTIR, UV–Vis spectra .
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