Intercellular adhesion molecules -1 (ICAM-1) and Vascular cell adhesion molecules-1 (VCAM-1) in hypertensive patients suffering from bacterial UTIs .
karbala journal of pharmaceutical sciences,
Volume 4, Issue 5, Pages 56-68
AbstractLeukocyte binding to cellular adhesion molecules (CAMs) on the surface of vascular endothelial cells appears to be one of the earliest events in the atherosclerotic process. In this study the concentration of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on lymphocytes were evaluated during vascular disease like hypertension . In addition level of CAMs in hypertensive patients in response to other factors like sex, aging , smoking , anti hypertension drugs treatment (mainly with some β-blockers(propranolol) or ACE inhibitors(captopril)) and UTIs were also measured . As compared to controls mean of ICAM-1 and VCAM-1 were significantly elevated in hypertensive subjects. VCAM-1 was significant in male compared to female . Significant positive correlation was observed of VCAM-1 level in relation to ageing , Smoking and in hypertensive patients suffering from UTIs. While the level of both ICAM-1 and VCAM-1 was found to be decreased upon anti hypertension treatment with either β-blocker or ACE inhibitor decreased.
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