Preparation and Evaluation of Sodium Fluoride Orodispersible Tablets
karbala journal of pharmaceutical sciences,
Volume 4, Issue 5, Pages 46-55
AbstractFluoride is used to prevent dental caries. Administration of fluoride tablet is an acceptable way for compensating the need for fluoride. The purpose of this study was to prepare orodispersible tablets of sodium fluoride and evaluation its physical properties as weight variation, hardness, disintegration, friability and release study. Different formulas of fast dissolving sodium fluoride tablets were prepared using direct compression method to enhance patient compliance using three different types of super disintegrants (sodium starch glycolate (SSG), croscarmelose (CC), and crospovidone (CP). Directly compressible mannitol was used as a diluent to enhance the mouth feel and compressibility, in addition to that, the prepared formulas were evaluated for hardness, friability, disintegration, dissolution time and content uniformity. Crospovidone was the best superdisintegrant used among croscarramelose sodium and sodium starch glycolate since crospovidone showed the fastest disintegration time (16±0.5, 15±0.5), and wettability (7± 0.5, 9±1) in F3, and F4 respectively, between croscarramelose sodium and sodium starch glycolate in addition to the acceptable hardness (4± 0.3), friability (0.962%) and taste also with dissolution time within 20 minutes and 55% drug release within 10 minutes for the selected formula F6. It was concluded that sodium fluoride can be prepared as orodispersible tablet using crospovidone as a superdisintegrant, manitol as a diluents and 15% sodium saccharine as a sweetener.
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