Hypolipidemic effect of date palm pollen and isolated flavonoids in sera of adult male rabbits
karbala journal of pharmaceutical sciences,
2013, Volume 4, Issue 5, Pages 34-45
AbstractThis study presents the effects of date palm pollen grains-DPP (Phoenixdactylifera) and isolated flavonoids on the level of cholesterol, triglycerides-TG, high-density lipoprotein cholesterol HDL-C, low-density lipoprotein cholesterol LDL-C and very low-density lipoprotein VLDL in sera of 49 adult male rabbits divided randomly into seven groups (7 animals in each group), in which G1, G2 and G3 treated with (30,60 and 90) mg/kg/day of DPP respectively, while the G4, G5 and G6 were treated with(7.5,15 and 30) mg /kg/day of isolated flavonoids from DPP respectively compared with non-treated group C1 as control. The results indicate that the level of cholesterol significantly decreased in sera of G1, G2 and G3, and also in sera of rabbits in G4 and G5as compared with C1, while the level of TG show slightly reduced in sera of G1,G3 and significantly increased in G6as compared with C1. In the other hand our results indicate that the important effect to improve the level of HDL-C may be due to the action of flavonoids at dose 15mg/Kg of body weight with no important effect of DPP to the serum level of HDL-C, and also reduced the levels of LDL-C in all groups treated with DPP and flavonoids, with no important effect to the level of VLDL-Cin sera of all groups.Our results also indicate that DPP grains and flavonoids have anti atherosclerotic effects in high dose. From all the above results we can conclude that pollen grains of date palm and its isolated flavonoids have hypolipidemic and anti atherosclerotic effects.
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