Study ofSeveral Anti oxidants , Total Acid Phosphatase, Prostatic Acid Phosphatase, Total and Free Prostate-Specific Antigen in Sera of Man with Chronic kidney failure
karbala journal of pharmaceutical sciences,
2013, Volume 4, Issue 4, Pages 155-165
AbstractChronic kidney failure (CKF),is a progressive loss in renal function over a period of months or years. The symptoms of worsening kidney function are unspecific, and might include feeling generally unwell and experiencing a reduced appetite. Free radicals are formed in all living organisms during normal cell metabolism. Patients with chronic renal failure who are regularlydialyzed are candidates for free radical damage.The current study investigate possible links with total acid phosphatase, prostatic acid phosphatase, total and free prostate-specific antigen ,several Antioxidants and an increased risk of prostate disease present in males with chronic kidney failure (CKF). The present study is also to compare these features level among patients [chronic renal failure] undergoing haemodialysisand in control (age and sex matched)therefore, addressed this question by measuring prostatic markers in patients receiving long-term dialysis.Patients were chosen from the patients referred to the Medical City –Kidney Transplant Center, Iraq.The glomerular filtration rate (GFR)has been measure in 45 patients with CKF using haemodialysis method . Laboratory investigations including kidney function, serum urea, creatinine, albumin, S. calcium, S. Phosphorus, total protein, Uric acid, S. potassium, S. Sodium,Hb, in addition to serum total antioxidant capacity(TAC), lipid peroxidation(the level of lipid peroxidation expressed as malondialdehyde(MDA)) ,vitamin E, vitamin C and total acid phosphatase, prostatic acid phosphatase, total and free prostate-specific antigen had been measured in male with CKF . Blood samples were obtained from the patients and the control group consisted of 25age and sex matched normal healthy individuals who came to the hospital for health checkup.Hemoglobin, Serum urea,creatinine,GFR, S. calcium, potassium,PSA, fPSA, PAP,LH, TAC,MDA, uric acid , vitamin E, vitamin C showed significant difference between the patients and control group. There was a positive correlation in PSA[ng/ml] with TAC (r=0.57, p<0.01), MDA (r=0.60, p<0.01),While PSA correlated negatively with Vitamin E (r=-0.65, p<0.01), Vitamin C (r=-0.57, p<0.01) in the CKF patients while there was no significant correlation was observe in the control group. In this study, a significantly negative association was observed between PAP[IU/L] with TAC (r=-0.63, p<0.01), MDA (r=-0.70, p<0.01),in the CKF patients while there was no significant correlation was observe in the control group. A significant positive correlation was found between PAP[IU/L] , and Vitamin E (r=0.61, p<0.01), Vitamin C (r=0.67, p<0.01).Hemodialysis leads to significant changes in the antioxidant system of the blood of patients with chronic renal failure. Despite an adverse metabolic environment in chronic renal insufficiency, Prostatic disease markers were useful in the routine screening of men receiving long-termdialysis, but the clinicians should be on alert when the dialysis duration increasesthe change in serum anti oxidants that accompanies decline in renal function.
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