Protective Effect of Terfeziaclaveryi Extract on Gentamicin-Induced oxidative stress in Rats
karbala journal of pharmaceutical sciences,
2013, Volume 4, Issue 4, Pages 40-50
AbstractGentamicin is one of the commonly use antibiotic for gram negative spectrum, and this drug is associated with nephropathy this due to the formation of reactive oxygen species. The aim of this study to evaluate the ability of Terfeziaclaveryi extract fortreatment the oxidative stress induced by using gentamicin. To reach our object 24 rats were divided in to four groupsall of themreceived water and standard diet while the treatment of the control groups were placebo treatments, the Gentamicin group received the drug with a ratio of 100mg/kg for 8 days, Terfeziaclaveryi group received oral dose of extract with a ratio of 250 mg/kg for the same period, the last group which is GentamicinTerfeziaclaveryi;received drug with a ratio of 100mg/kg and in the same time received oral dose of extract with a ratio of 250 mg/kg for 8 days. The results show significantly increase in serum urea and creatininewhich is associated with histopathologicaldamage of the kidney tissue'sarchitecturedue to the administration of the gentamicin and this increase or damage is positively correlate with concentrations of the kidney MDA and negative correlation with the activity of catalase, superoxide dismutase and glutathione peroxidase on the kidney tissue homogenate, this modulation of the biological parameter histological damage is significantly neutralized by the administration of the Terfeziaclaveryi extract, from which we can conduct that administer of the Terfeziaclaveryi extract reduce the toxicity and damage caused by the gentamicin.
Key words: Terfeziaclaveryi, gentamicin, oxidative stress
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