Effect of Morin on Isoniazid and Rifampicin Induced Hepatotoxicity in Rats
karbala journal of pharmaceutical sciences,
Volume 4, Issue 4, Pages 32-39
AbstractThe first line drugs used for tuberculosis therapy are isonizid and rifampicin (INH
&RIF) and they are associated with hepatotoxicity, for this reason we aimed to study
the protective effect of morin on the hepatotoxicity induced by the tow
antituberculosis agents given together.
To reach study object 24 female Wistar albino rats 220-250 g were divided into four
groups, each group consisted of six animals received standard diet and tab water along
the 21 days which is the experimental period. The control groupleaved without
treatments while the morin group, rats were treated with 30mg/kg/day morin via
gavage along the days of the experiment. INF-RIF group, rats were treated with 100
mg/kg/day INH-RIF by intraperitoneal injection method for 21 days. INF-RIF and
morin group, rats were treated with 100 mg/kg/day INH-RIF plus morin with a dose
of 30 mg/kg /day via gavage along the experimental period.
The results had a significant increase in the activity of alanine aminotransferase,
aspartate aminotransferase and malondialdehyde level and significant decrease in the
activity of superoxide dismutase, glutathione peroxidase, glutathione s-transferase and
catalase in animal groups treated with INH and RIF as compared to control groups.
However, supplementation of INH-RIF intoxicated rats with morin ameliorated the
antituberculosis drugs adverse effects as evidenced by a significant decrease in
alanine aminotransferase, aspartate aminotransferase activity and malondialdehyde
level and significant increase in superoxide dismutase, glutathione peroxidase,
glutathione s-transferase and catalase. We concluded that morin have a potential to
protect the liver from INH and RIF toxicity.
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