Phytochemical Study of some Flavonoids Present in theFruit Peels of Citrus reticulata Grown in Iraq.
karbala journal of pharmaceutical sciences,
Volume 3, Issue 3, Pages 136-151
AbstractCitrus reticulata (Tangerine) of the familyRutaceaeis widely growing in Iraq, Literature survey reveal that there was no phytochemical study concerning C.reticulatafruitpeelsin Iraq. Flavonoids from citrus genus have been of particular interest because of their broad spectrum of biological activities, including anti-inflammatory, anticarcinogenic, and antiatherogenic properties. Therefore, the isolation and characterization of flavonoids fromC. reticulata fruit peels will lead to new applications of the byproducts from citrus juice processes and other citrus consumption in nutraceutical and pharmaceutical products. Literature survey also reveal that C.reticulata fruitpeels were widely used by the ancients for treatment of different kinds of diseases; therefore a research on Iraqi C.reticulatafruitpeels will be of important value. This study is concerned with the extraction, identification, isolation& purification of some biologically important flavonoids in Iraqi C.reticulatafruitpeels including:Tangeretin, Nobiletin, Hesperidin&Quercetin.Extraction was carried out by two methods includingSoxhlet apparatus&Maceration.Two flavonoids which are Tangeretin &Nobiletin were isolated, purified& quantitatively estimated while Hesperidin&Quercetin were identified by thin layer chromatography (TLC) & this identification was further augmented by using High performance liquid chromatography (HPLC). The identification of the isolated compounds (Tangeretin &Nobiletin) was done by measuring the melting point (M.P.), TLC where different solvent systems had been used, HPLC& infrared spectroscopy (IR). The most suitable extraction & identification methods were fully described in this study. This study confirms the presence of Tangeretin, Nobiletin, Hesperidin&Quercetin inthe fruit peels of C.reticulata grownin Iraq, these compounds have important medicinal & therapeutic values that are mentioned in this study. The percentages of Tangeretin &Nobiletin werehigher in the extract obtained by soxhlet apparatus than that obtained by maceration.
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