FI - Spectrophotometric Determination of PropranololHydrochloric in pharmaceutical preparations
karbala journal of pharmaceutical sciences,
Volume 3, Issue 3, Pages 107-116
AbstractA batch and flow injection spectrophotometric method is described for the determination of propranololhydrochloride in pure and pharmaceutical formulations. The proposed method based on the diazotization of 4-amino-6-chlorobenzene-1,3-di sulfonamide and followed by coupling with propranolol hydrochloride in the presence ofsodium hydroxide to form orange soluble dye that has a maximum absorption at 490 nm. The optimum reaction conditions and other analytical parameter are evaluated. A graph of absorbance versus concentration shows that Beer's law is obeyed over the concentration range of (0.25 – 10.00µg/ml) and from (1.20 – 48.00µg/ml),with a limit of detection(signal / noise =3) of 0.145µg/mland 0.640µg/ml.The correlation coefficient was 0.9997 and 0.9998 by batch and FI procedure respectively. The method was applied successfully for the determination of propranolol hydrochloride in pharmaceutical preparations. The relative standard deviation was better than 0.79 % (n=10) .
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