Preparation and in vitro evaluation of pH sensitive swelling interpenetrating polymer network
karbala journal of pharmaceutical sciences,
Volume 2, Issue 2, Pages 1-14
AbstractThe semi-interpenetrating polymer network (semi-IPN) is a polymer blend consisting of crosslinked polymer network interpenetrated by linear-chain or branched-chain macromolecule. It was developed to impart promising pH sensitive and swelling properties. The casting method was used to formulate pH sensitive semi-IPN using chitosan and polyvinylpyrrolidone (PVP). The results revealed that the freeze-dried formulas were swelled to very high extent (up to 57.81 folds within 5min) , while the swelling of the air-dried formula didn’t exceed 13.15 folds. Also increasing proportion of PVP from 1.5 to 4.5 relative to chitosan was accompanied by increasing the folds of maximum swelling of network (from 10.90 to 13.15 folds respectively).
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