Role of Eruca sativa in prevention of induced nephrocalcinosis in rabbits
karbala journal of pharmaceutical sciences,
2018, Volume 9, Issue 14, Pages 65-73
AbstractBackground: Nephrocalcinosis is a clinical pathologic condition characterized by abnormal deposition of calcium phosphate or calcium oxalate in the renal parenchyma, which can result in impaired kidney function.
Aim: This study aimed to evaluate the effect of Eruca sativa aqueous extract in prevention of nephrocalcinosis induced by a large dose of oxalic acid in rabbits.
Materials and Methods: Twenty four healthy domestic rabbits were equally allocated into three groups and were distributed into: normal group (without drug), oxalic acid group and Eruca sativa group. Both the first and second groups were received distilled water, while the third group received aqueous extract of Eruca sativa for ten consecutive days. Single high dose of oxalic acid was given to induce nephrocalcinosis in rabbits of the second and third groups (except normal group) after 2 hours from receiving of distilled water and Eruca sativa extract at the first day. Blood samples were collected from all animals for biochemical analysis. Urine analysis and histopathological examination were performed for all rabbits to verify the presence of crystals in urine and renal tissues.
Results: Eruca sativa aqueous extract produced highly significant reduction in blood urea nitrogen, serum creatinine , with significant reduction in serum Na+ , and highly significant elevation in serum Ca2+ and serum K+ levels, also it is produced highly significant reduction in the calcium oxalate crystals density in urine and renal tissues when compared with of oxalic acid group.
Conclusion: Current study found that the aqueous extract of Eruca sativa effectively prevented the formation and deposition of calcium oxalate crystals in renal tissues, thus preventing the occurrence of nephrocalcinosis.
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