BUCCOADHESIVE TABLETS OF TRIFLOUPERAZINE: FORMULATION, EVALUATION AND EFFECT OF FORMULATION PARAMETERS
karbala journal of pharmaceutical sciences,
2017, Volume 8, Issue 13, Pages 299-310
AbstractBuccal drug delivery has become one of the popular delivery systems due to its comparable and significant advantages over the conventional dosage form. Trifluoperazine is an antipsychotic which is a phenothiazine compound. It is mainly used for schizophrenia. This work presents different formulations of trifluoperazine HCl as a mucoadhesive tablet by using various polymers in order to avoid the effect of 1st pass metabolism; hence, improve the drug bioavailability as well as to obtain better patient compliance. The tablets compressed by direct compression and designed to provide the release of drug from one side and using ethyl cellulose (EC) to cover the other side. Various polymers were employed such as carbapol 934 (CP 934), chitosan, guar gum, sodium carboxymethylcellulose (SCMC), hydroxypropyl methylcellulose K4M (HPMC K4M) and others. The formulations (F1-F12) were undergoing different evaluations as ex vivo and in vitro methods and statically analyzed the bioadhesion, swelling index and in-vitro release of drug. The results showed that F6 which included SCMC in addition to CP 934 was giving the optimum release of 91.95%, swelling index of 87 after 6 hours and mucoadhesive strength equal to 20.12 g.
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