The effect of olive oil (Olea europaea) on ibuprofen induced hepatotoxicity in female rats
karbala journal of pharmaceutical sciences,
2017, Volume 8, Issue 13, Pages 178-187
AbstractIbuprofen, a propionic acid derivative, is one of the most commonly Non-steroidal anti-inflammatory drugs, which are among the most frequently prescribed medications worldwide. The aim of this study is to investigate the protective effect of olive oil against ibuprofen-induced hepatotoxicity in female albino rats. In this study we used 24 female white rats and divided them into 4 equal groups. Each experimental group consisted of 6 animals. Group1,control they were fed on diet and water without any treatment ,group2, ibuprofen given at dose 40 mg/kg/day orally by gastric tube for 30 days, group3,olive oil 2 ml/kg/day (oral administation), group 4, ibuprofen at dose of 40 mg/kg/day and olive oil 2 ml/kg/day (oral administration).Treatments were administered once daily for 30 days. After 30 days, biochemical and histopathological analysis were conducted to evaluate hepatotoxicity. Serum levels of albumin, total proteins, and activity of AST, ALP, ALT and total bilirubin were measured. Animals treated with ibuprofen alone showed a significant increase in serum levels of ALT, AST and ALP and significant decrease in albumin and total proteins. Treatment of rats with olive oil showed significant improvement in hepatic function , presumably as a result of decreased boichemical parameters associated with ibuprofen-induced hepatotoxicity. Histopathological examination of the rats liver confirmed these observations. Therefore olive oil may protect against ibuprofen-induced hepatotoxicity.
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