Synthesis and characterization of new complexes of schiff bases derived from "sulfanilamide" with metal ions Hg+2, Zn+2 and evaluation their biological activity
karbala journal of pharmaceutical sciences,
2016, Volume 7, Issue 11, Pages 299-313
AbstractA new four Schiff bases synthesized by the condensation of the aromatic amine
compound: 4-amino benzenesulfonamide with the four aromatic aldehyde
compounds: 4-chloroBenzaldehyde, 4-BromoBenzaldehyde, 4-HydroxyBenzaldehyde
and 4-(N,N-dimethyl) aminoBenzaldehyde, Also a complexes of pervious ligands were
synthesized with the metal ions with molarity ratio (1:2) M:L. The synthesized
compounds were characterized by physical and spectroscopic measurements (IR
spectrum and proton NMR spectrum, elemental analysis C.H.N, Molar conductivity).
All the synthesized complexes were formed tetra-coordinate complexes and the
supposed chemical formula of the consequent complexes:[M(L)2Cl2]. The Biological
activity were evaluated for the synthesized compounds against two types of bacteria
E.Coli and S.aureus, most of complexes shown anti-bacterial activity.
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