Serum procalcitonin and plasma D-Dimer evaluation in pregnancy Conjugate with pre-eclampsia mild & severe pre-eclampsia versus normal pregnancy
karbala journal of pharmaceutical sciences,
Volume 7, Issue 11, Pages 166-178
AbstractPre- eclampsia is a common and heterogeneous syndrome of human
pregnancy. Normal pregnancies are associated with inflammatory and hemostatic
changes. The maternal syndrome of pre- eclampsia results from a systemic
inflammatory response that involves the entire inflammatory network of the
circulation, including the endothelium. Procalcitonin is an inflammatory marker
which is raised in pre eclampsia .Normal pregnancy causes the maternal plasma DDimer
level to increase progressively from conception until delivery .It is accepted
that the hemostatic system is disturbed in pre eclamptic patients , but the effect or
relationship with d dimer level and PET remains to elucidate .
Aim of this study was to evaluate serum procalcitonin (PCT) , and plasma DDimer
levels in mild and severe pre-eclampsia.
Prospective case control study carried out in department of obstetrics and
gynecology /Baghdad Teaching Hospital /Medical City /Baghdad /Iraq .
Serum procalcitonin (PCT), and D-Dimer levels were determination in 40
cases with pre-eclampsia as the study group and 40 healthy pregnant women in the
third trimester as the control group. Pre-eclamptic group consisted of mild (n = 20)
and severe pre-eclamptic subgroup (n = 20).
Laboratory results were compared between the groups and diagnostic usefulness of
these parameters were evaluated.
Serum procalcitonin (PCT) PCT, and D-Dimer levels were significantly
higher in study group than the control group (P <0.001). PCT, and D-Dimer were
significantly higher in the patients with severe pre-eclampsia than mild VIII preeclampsia(
p=0.012)There were significant positive correlations between these
markers and mean arterial pressure (MAP). Logistic regression analysis using the
control and pre-eclampsia group showed that higher PCT (OR,6.12; 95%-CI, 3.30-
13.50), and D-Dimer levels (OR,4.41; 95%-CI,2.8-9.18)were found to be risk factors
significantly associated with pre-eclampsia.
This study results confirm that evidence of a possible exaggerated systemic
inflammatory response in pre eclampsia especially
in severe pre- eclampsia
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