Formulation &invitro evaluation of clarithromycin floating microsponge capsule
karbala journal of pharmaceutical sciences,
Volume 7, Issue 11, Pages 27-35
AbstractObjective: The aim of this study is to formulate microsponge of clarithromycin capsule
dosage form and evaluate the release profile in comparing with marketed clarithromycin
Methods: clarithromycin microsponge was prepared by quasi-emulsion solvent diffusion
method by using polymers Eudragite RL100 in organic solution as internal phase and
aqueous solution of polyvinyl alcohol as external phase. The compatibility of the drug
with formulated components was established by Fourier Transform Infra-Red (FTIR)
spectroscopy. The prepared microsponge powder was evaluated for angle of repose,
Carr's Index ,particle size, floating time production yield, drug loading efficiency of
microsponges and release profile in comparison with marketed drug.
Results: Formulation F4 with a ratio 8:1 drug to polymer, and 0.25% polyvinyl
pyrrolodine solution was the best formulation showing the highest degree of sustained
release that was 79.59% at the end of 12 hours with a floating time capsule 12 hr.
Eudragit RL 100 could control drug release in stomach.
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