Formulation of telmisartan microsponge tablets and In-Vitro evaluation of dissolution profile
karbala journal of pharmaceutical sciences,
2015, Volume 6, Issue 9, Pages 91-104
AbstractObjective: The aim of this study is to formulate microsponge of telmisartan as a tablet dosage form
and evaluate the release profile in comparing with Micardis® the marketed telmisartan..
Methods: Temisartan microsponge was prepared by quasi-emulsion solvent diffusion method by
using polymers either Eudragite E or eudragite L in organic solution as internal phase and aqueous
solution of polyvinyl povidone as external phase. Five formulations of microsponge temisartan
tablet were prepared including formulation 3 which contains pure telmisartan by direct compression
method. All formulations were evaluated for flowability characteristic and release profile in
comparison with marketed tablet Micardis®.
Results: Telmisartan microsponge was successfully formulated without any interaction or in
compatibility with Eudragite polymer. The flow properties of the microsponge powder were with
acceptable limit. The wetting and disintegration time of F1, F2, F4 and F5 in microsponge system
were decrease in comparison to the F3 which used plain telmisartan and Micardis® a conventional
tablet. The superdisintegrants crospovidone 5% which represented in formula F4 and F5 gave the
rapid disintegration time compared to the other formulas. The dissolution profile of the temisartan
for all formulation and comparing to the Micardis tablet indicated the improvement of the
dissolution rate by using microsponge system.
Conclusion: It was indicated that telmisartan microsponge was successfully formulated and their
tablet formulations proved to show better release profile in all aspects as compared to marketed
(Micardis®) tablet. Using of different super disintegrates have significant effect on wetting and
disintegration time of telmisartan tablet.
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