Synthises and characterization of New fructosyl N-ampicillin derivative as possible prodrug
karbala journal of pharmaceutical sciences,
2015, Volume 6, Issue 9, Pages 61-69
Abstract“Prodrugs Approach” is a versatile approach in solving the problems associated with drug
molecules. Ampicillin drug has some side effects i.e. absorption, toxicity, distribution,
instability, formulation etc. These side effects can be reduced by “Prodrugs Approach”. In the
present research work a new carbohydrate derivative of N-ampicillin was prepared by
reacting the appropriate 1-chloro-diacetone fructose with protected ampicillin anhydrous to
obtain a new ampicillin amino derivative as possible prodrug , that has more water–solubility
than parent drug make to reduce the dose given to patient and reduced the dugs side effect .
The synthesized compounds were identified using U.V, FT-IR and 1H-NMR spectra and it
was equal to expected. The synthesized compound was tested for their antifungal and
antibacterial activities in vitro. However, detailed kinetic studies of chemical and potential
enzyme hydrolysis still remain to be done.
- Article View: 45
- PDF Download: 37