ISSN: 7027-2221

Keywords : Olive oil


The effect of olive oil on ibuprofen induced Renal toxicity in female rats.

Mohammed Talat Abbas; Rabab Murtadha Abed; Nazar Jabar Metab

karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 167-177

Ibuprofen is an effective, cheap, and it is one of the most commonly non-steroidal anti-inflammatory drug, which are among the most frequent prescribed medications worldwide .The aim of this study is to investigate the protective effect of olive oil against ibuprofen-induced nephrotoxicity female albino rats. In this study we used 24 female white rats and divided them into 4 equal groups. Each experimental group consisted of six animals. group1, control they were fed on diet and water without any treatment, group2, ibuprofen given at dose 40 mg/kg/day orally by gastric tube for 30 days, group3,olive oil 2 ml/kg/day (oral administration) , group4, ibuprofen at dose of 40 mg/kg/day and olive oil 2 ml/kg/day (oral administration).Treatments were administered once daily for 30 days. After 30 days, biochemical and histopathological analysis were conducted to evaluate nephrotoxicity. Serum levels of urea, creatinine, calcium, glucose, phosphorus and amylase were measured. Animals treated with ibuprofen alone showed a significant increase in serum levels of urea, creatinine and glucose and significant decrease in calcium. Treatment of rats with olive oil showed significant improvement in kidney function, presumably as a result of decreased boichemical parameters associated with ibuprofen-induced nephrotoxicity. Histopathological examination of the rats kidney confirmed these observations. Therefore olive oil may protect against ibuprofen-induced nephrotoxicity.

The effect of olive oil (Olea europaea) on ibuprofen induced hepatotoxicity in female rats

Mohammed Talat Abbass; Rabab Murtadha Abed; Nazar Jabar Metab

karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 178-187

Ibuprofen, a propionic acid derivative, is one of the most commonly Non-steroidal anti-inflammatory drugs, which are among the most frequently prescribed medications worldwide. The aim of this study is to investigate the protective effect of olive oil against ibuprofen-induced hepatotoxicity in female albino rats. In this study we used 24 female white rats and divided them into 4 equal groups. Each experimental group consisted of 6 animals. Group1,control they were fed on diet and water without any treatment ,group2, ibuprofen given at dose 40 mg/kg/day orally by gastric tube for 30 days, group3,olive oil 2 ml/kg/day (oral administation), group 4, ibuprofen at dose of 40 mg/kg/day and olive oil 2 ml/kg/day (oral administration).Treatments were administered once daily for 30 days. After 30 days, biochemical and histopathological analysis were conducted to evaluate hepatotoxicity. Serum levels of albumin, total proteins, and activity of AST, ALP, ALT and total bilirubin were measured. Animals treated with ibuprofen alone showed a significant increase in serum levels of ALT, AST and ALP and significant decrease in albumin and total proteins. Treatment of rats with olive oil showed significant improvement in hepatic function , presumably as a result of decreased boichemical parameters associated with ibuprofen-induced hepatotoxicity. Histopathological examination of the rats liver confirmed these observations. Therefore olive oil may protect against ibuprofen-induced hepatotoxicity.

The use of three to five Tablespoonful per day of garlic ,olive and sesame oil mixture can improve health of patients suffering from rheumatoid arthritis disease

Ali jalil Ali

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 1-14

Background: Rheumatoid arthritis (RA) is an autoimmune disease where the body immune system
attacks different normal joint tissues organs causing inflammation of the joint lining . Rheumatoid
arthritis still one of an important diseases affecting large population. Different kinds of medicine
where used but still the needs for extra herbal medicine that assist and improve patients movements
is needed for decreasing patients compliance. This study summarized the benefit of using Garlic,
Olive and Sesame oil (GOS) mixture on patients health though its anti-inflammatory and antibacterial
effects and this effect was seen after using mostly three to five tablespoonful/day. Such
results was confirmed by decreasing most of inflammatory markers (Erythrocyte sedimentation rate
(ESR), Rheumatoid factor (RF), Neutrophile count, anti-cyclic citrullinated peptide antibody (Anti-
CCP) level and bacterial growth) with improving patients health. Aim of the study: to study the
efficiency of garlic oil, olive oil and sesame oil mixture in treatment of Rheumatoid arthritis
disease. Methods: A 80 serum samples (27 women and 43 men; mean age 45.5 ± 13.8 years; range, 25-
74 years) of patients with sign and symptoms of Rheumatoid arthritis attending Karbala Teaching
Hospital for Rheumatology department were studied. The patients were divided into three groups
:1- Twenty- five rheumatic patients were advised to administer five tablespoonful / day from
mixture containing GOS oil . 2- Thirty-five rheumatic patients were advised to administer three
table spoonful/ day of mixture containing GOS oil.3- Twenty patients were advised to administer
one tablespoonful/ day of mixture containing GOS oil. All the groups were advised to use topical
ointments containing mixture of GOS oil for 30 days. Inflammatory blood marker like Erythrocyte
sedimentation rate (ESR) , Rheumatoid factor (RF), Neutrophile count and Anti-CCP level in
addition to bacterial growth was evaluated before and after administration of GOS oral and topical
mixture.
Results: The results demonstrated that the level of ESR was decreased upon oral (three and five
tablespoonful/day) and topical use of GOS mixture. While RF level decreased if the patients use
five tablespoonful/day compared to three tablespoonful/day which show slight decrease in RF
level. However, Neutrophiles count was also found to be reduced during administration of three
tablespoonful/day while dosing of five and one tablespoonful/day shows a similar level of
reductions.
Anti-cyclic citrullinated peptide antibody regarded one of specific test for diagnosis of RA
disease. Five tablespoonful/day the patients describe a slight decline in the curve compared
with (three tablespoonful/day) that will have a sharp decrease in Anti-CCP level with
subsequent improvement in patients health . However, one tablespoonful/day , have relatively a
similar effect on Anti-CCP level to that of five tablespoonful/day). Bacterial growth profile was
found in all patients to be reduced sharply upon using GOS mixture. This decrease mostly
associated with the use of (three tablespoonful/day, five tablespoonful/day and one
tablespoonful/day) respectively.
Conclusion: Administration of oral (three to five tablespoonful/day) of GOS mixture was found to
reduce sign and symptom of RA disease with subsequent improvement in patients health. Such
results was accompanied by decreased in RA blood marker (ESR, RF, Neutrophiles count and Anti-
CCP ) level. In addition, to the reduction in bacterial growth. However, a further study is required
to investigate the effect of GOS mixture in compared to other anti-rheumatic drugs effects.

Effect of Olea Europea ( Olive oil ) on gentamicin induced hepatorenal toxicity in male rats

MOHAMMED TALAT ABBAS; ALI JELEEL ALI; IBRAHIM S.ABBAS; NEZAR METAB; HASSENEIN NOOR HADI; KASIM SAKRAN ABBAS; NEJDET ALI; Akram Abd AL- Hussein; Ayat Burhan; Tuka Hassan; Hiba Jalal

karbala journal of pharmaceutical sciences, Volume 6, Issue 10, Pages 0-0

Gentamicin is aminoglycoside antibiotic commonly used for the treatment of
Gram-negative bacterial infection. In many cases, it has been the only effective
therapeutic drug against bacterial strains resistant to other antibiotics, but nephrotoxicity
and hepatotoxicity side effects limit its use. The aim of this study is to investigate the
protective effect of olive oil against gentamicin-induced hepatorenal toxicity in male
albino rats. In this study we used 24 wistar-albino rats and divided them into 4 equal
groups. Each experimental group consisted of six animals. group1,control they were
given normal saline only ,group2,gentamicin 100 mg/kg/day intraperitoneal
(IP),group3,olive oil 5 ml/kg/day (oral administation) ,group 4,gentamicin 100 mg/kg/day
intraperitoneal (IP) and olive oil 5 ml/kg/day (oral administration).Treatments were
administered once daily for 21 days. After 21 days, biochemical and histopathological
analysis were conducted to evaluate hepatoranal toxicity. Serum levels of urea,
creatinine, cholesterol,triglyceride,and activity of AST and ALT were measured.Animals
treated with gentamicin alone showed a significant increase in serum levels of these
markers.Treatment of rats with olive oil showed significant improvement in renal and
hepatic function , presumably as a result of decreased boichemical parameters associated
with gentamicin-induced hepatorenal toxicity.Histopathological examination of the rats
kidneys and liver confirmed these observations. Therefore olive oil may protect against
gentamicin-induced hepatorenal toxicity