Keywords : Antibacterial activitie
Synthesis, Characterization and study of antibacterial activity in vitro of some hydrazones and formazan dyes containing benzothiazole moiety
karbala journal of pharmaceutical sciences,
Volume 4, Issue 5, Pages 81-90
2-mercaptobenzothiazole (I) on treatment with hydrazine hydrate and HCl by two methods, µW and direct heating with solvent, give 2- hydrazinobenzothiazole (II), which on condensation by µW and direct heating with substituted aromatic aldehydes affords aryl substituted (1,3-benzothiazole-2-yl)hydrazone (III). The latter on treatment with aryl diazonium chloride at low temperature degree furnishes respective 1-(benzothiazol-2-yl)-5-(4-sub.phenyl)-3-arylformazan(IVa-e,Va-e,VIa-e)(formazan dyes) which on have been used as pigments for cotton, wool and white wood, and showed a significant value and also showed a resistance for primary washing process.
The antibacterial activities of these compounds have been assayed against various Gram -ve and Gram +ve organisms. The structures were elucidated and spectral behaviors were investigated with the use of 1HNMR, 13CNMR, FTIR, UV–Vis spectra .