ISSN: 7027-2221

Keywords : Acacia


Preparation and in vitro Evaluation of Acyclovir Suspension

Ahmed N. Abood

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 95-109

The suspension is one of the successful oral liquid dosage forms. It has many
advantages such as increase the bioavailability of poorly water soluble drugs.
Acyclovir is poorly water soluble drug. It is antiviral agent, which is commonly
indicated for treatment of wide variety of viral infections; e.g., herpes simplex,
varicella zoster in children and adults.
The aim of this study, was preparation of acyclovir suspension dosage form using
single ionic type surfactant; sodium stearate was used as suspending and flocculating
agent. The flocculating ability of sodium stearate was assessed via measuring the
sedimentation volume. Acacia also was added as thickening agent and its ability to
impart a more stable successful suspension was evaluated. In this work, the
sedimentation volume, content uniformity and viscosity were studied for several
formulas containing different ranges of sodium stearate (from 0.5% to 3) in
combination with or without acacia at different concentrations (1% to 2%). Sodium
stearate was found to be able to give a flocculated system at concentrations higher
than 1%. The sedimentation volume (F) was found to be equals to (F= 1), which is an
ideal flocculated system; however, the resultant dispersion is thick and very hard to be
handled. Also the addition of acacia did not enhance the stability of the dispersed
system.