ISSN: 7027-2221

Keywords : Prodrug

Synthesis of N- Drug MaleamideChitosan Drug polymers

Firyal M.A; Saadoon A.A; Faris H.A.M

karbala journal of pharmaceutical sciences, Volume 6, Issue 10, Pages 0-0

In this research a new prodrug chitosan maleamide derivatives were
synthesis via reaction of amino group of chitosan with maleic anhydride then
converted to its corresponding acyl chloride, of the chitosan maleate
derivative (A1) was reacted with different drug-NH2 (A2-A5) such as
procaine, cephalexin, amoxicillin, and 4-aminoantipyrine.which could have
potential use as a natural drug delivery system as a sustain release through
hydrolysis of amide attachment in different pH values such as in acidic or
basic medium. These derivatives were characterized by FTIR and 1H-NMR
spectroscopies. Controlled drug release was studied using UV. Spectroscopy
at λmax 270nm gave a constant swelling percentage were measured indicated
controlling release with other advantages and to minimize the toxicity and the
side effect. Thermal analysis such as TGA and DSC were studied indicated
the thermally stableprodrug polymers.