ISSN: 7027-2221

Keywords : Floating

Effect of Hydroxy Propyl Methyl Cellulose (HPMC) on Amoxicillin Floating Tablet

Rahma Hussein Salim; Ayat Karim Hassan; Noor Qasim Al-tamemi; Ashti M. Saeed; Hasanain Sh. Mahmood; Zaid AL-Obaidi; Jinan M. Almusawi; Maryam H. Alaayedi

karbala journal of pharmaceutical sciences, 2017, Volume 8, Issue 13, Pages 311-319

Amoxicillin is a broad spectrum antibiotic which has been used for treatment range of infections including Helicobacter pylori. Formulating a locally release drug delivery is preferred for better amoxicillin action. Floating dosage form is a candidate for carrying the drug which reserve drug in the upper gastrointestinal tract (GIT). Hydroxypropyl methyl cellulose (HPMC) was studied in this research to determine its effect on floating characteristics of amoxicillin tablet. Seven formulas of amoxicillin floating tablet were prepared by direct compression method. The results showed that using about 11% of the polymer gave better floating lag time (about 3 minutes) and floating duration (more than 5 hours) to be optimized formula in comparing with others.