Keywords : CAM assay
karbala journal of pharmaceutical sciences,
Volume 8, Issue 13, Pages 1-9
The objective of this study is to identify the possible anti – angiogenic activity of Cuminum cyminum seeds extract in vivo assays. Cuminum cyminum seeds powder was extracted by methanol using the cold method "maceration" as extraction process. The in vivo study was done by Chick Chlrioallontoic Membrane assay (CAM assay).Then phytochemical analysis done by Gas Chromatography mass spectroscopy (GC). The obtained data revealed that methanolic extract of Cuminum cyminum seeds significantly inhibit blood vessels growth when it compared to negative control and the inhibition zone about (++). And according to GC mass the extract showed chemicals related poly phenol group like tannins and flavonoids that may be responsible on anti angiogenic activity of Cuminum cyminum seeds.