ISSN: 7027-2221

Keywords : hypertension


Relationship between Transforming Growth Factor-Beta 1 gene polymorphism and hypertension

Fadhil Jawad Al-Tu; Zena Abdul-Ameer Mahdi; Hassan Ali Nassrallah

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 225-235

This study intends to evaluate the association between Transforming Growth Factor - Beta1
(TGF-β1) SNP codon 25 and hypertension in holy Kerbala city, Iraq. A case control study
for one hundred and four subjects. Seventy four hypertensive patients (23 male and 51
female), already diagnosed with essential hypertension, and 30 control subjects (16 male
and 14 female). The links between genotype and hypertension were examined then possible
SNP related variances in the blood pressure were checked. The present study suggested that
there is no significant association between transforming growth factor beta one (TGF-β1)
and hypertension in its Iraqi population sample. However, there is a significant association
between Arginine (Arg25) and hypertension compared with control group clearly shown in
the male gender (p < 0.05). In this study, the associations between the SNP of TGF-β1
codon 25 and hypertension was not significant while the SNP showed genotype-related
differences in gene allele (Arg25).

Intercellular adhesion molecules -1 (ICAM-1) and Vascular cell adhesion molecules-1 (VCAM-1) in hypertensive patients suffering from bacterial UTIs .

Nidhal abdul Mohaimen; Arif Sami; Zainab Thamer Showait Al-assady

karbala journal of pharmaceutical sciences, Volume 4, Issue 5, Pages 56-68

Leukocyte binding to cellular adhesion molecules (CAMs) on the surface of vascular endothelial cells appears to be one of the earliest events in the atherosclerotic process. In this study the concentration of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on lymphocytes were evaluated during vascular disease like hypertension . In addition level of CAMs in hypertensive patients in response to other factors like sex, aging , smoking , anti hypertension drugs treatment (mainly with some β-blockers(propranolol) or ACE inhibitors(captopril)) and UTIs were also measured . As compared to controls mean of ICAM-1 and VCAM-1 were significantly elevated in hypertensive subjects. VCAM-1 was significant in male compared to female . Significant positive correlation was observed of VCAM-1 level in relation to ageing , Smoking and in hypertensive patients suffering from UTIs. While the level of both ICAM-1 and VCAM-1 was found to be decreased upon anti hypertension treatment with either β-blocker or ACE inhibitor decreased.

Effect of gender , aging , smoking and urinary tract infections on level of CD4+ T lymphocytes in hypertensive patients treated with propranolol and captopril drugs

Nidhal abdul mohaimen; Arif sami; Zainab Thamer showait al-assady; Ali jalil ali

karbala journal of pharmaceutical sciences, Volume 4, Issue 5, Pages 69-80

Forms of adaptive response may be useful markers of endothelial activation and local or systemic inflammation. In this study the CD4+ T lymphocytes were evaluated during vascular disease like hypertension and the effect of other factors like sex, aging , smoking , anti hypertension drugs treatment (mainly with some β-blockers or angiotensin converting enzyme inhibitors) and urinary tract infections on expression of the CD4+ T lymphocytes were also studied . The results showed that mean level of CD4+ T lymphocytes was increased in hypertensive patients (p≤ 0.01) and this increase is more in female compared to male . Level of CD4+ T lymphocytes was significantly elevated in hypertensive subjects with age group of 30-40 years and the level started to decreased with aging. However, upon treatment with antihypertensive drugs (mainly β-blocker or angiotensin enzyme inhibitors) the level of CD4+ T lymphocytes was reported to decreased . CD4+T lympho-cytes level was significantly increased in hypertensive smoking patients(P ≤ 0.01) and in patients suffering from urinary tract infections (UTIs) .