ISSN: 7027-2221

Keywords : thiadiazole

Synthesis and study the biological activity of some new heterocyclic compounds

Ahmad Waaled; Salwa A. Jabbar; Ibtisam K. Jassim

karbala journal of pharmaceutical sciences, 2015, Volume 6, Issue 10, Pages 0-0

This work involves synthesis of different types of heterocyclic compounds. These
compounds including oxadiazole rings and its derivatives. These compounds containing thioester
linkage by reacting the oxadiazoles with different acid chlorides. The prepared compounds were
characterized by FT-IR,H-NMR- MASS and UV/vis spectroscopy.

Synthesis of novelN-{5-(2,2-Dimethylisopropylidenyl)thio-1,3,4-thiadiazolyl}-N-acetyl-amino-(4-(N-Dimethylamino)benzyl –amino Barbituric Acid

Fadhel; OmranEssa; kadhumJwad AL-Hmdani; Abbas; Ali .Drea

karbala journal of pharmaceutical sciences, 2013, Volume 4, Issue 4, Pages 51-64

5-amino-1,3,4-thiadiazole-2-thiol (1) was reacted with4-(N-dimethylamino)benzaldehyde in refluxing ethanol to give Schiff base 5-{[4-(dimethylamino)benzylidene]amino}-1,3,4-thiadiazole-2-thiol (2) .Compound (2) was reacted with Acetylchloridein dry benzene to giveN-{chloro[4-(dimethylamino)phenyl]methyl}-N-(5-mercapto-1,3,4-thiadiazol-2-yl)acetamide(3) the reaction of compound (3) with quindinehydrochloridin ethanol to gave N-{5-mercapto(1,3,4-thiadiazol-2-yl) }-amino-N-acetyl -4-(N-dimethyl amino benzyl) guanidine (4)
Compound(4)was reacted with dimethylmalonate in ethanol to afford N-{ 5-mercapto(1,3,4-thiadiazol-2yl)}-amino-N-acetyl -4-(N-dimethylaminobenzyl)aminobarbituric acid (5), these compounds were reacted with 2,2-dimethyl-4-[(phenylsulfonyl)methyl]-1,3-dioxolane in dioxane to give N-{5-(2,2-Dimethylisopropylidenyl)thio-1,3,4-thiadiazolyl}-amino-N-acetyl -(4-(N-Dimethylamino)benzyl –amino barbituric Acid(6)
The prepared compounds were identified by elemental analysis and spectroscopic methods :FT-IR,UV-visible and 1HNMR for compounds (4-6)