ISSN: 7027-2221

Keywords : Hepatorenal toxicity


Effect of Olea Europea ( Olive oil ) on gentamicin induced hepatorenal toxicity in male rats

MOHAMMED TALAT ABBAS; ALI JELEEL ALI; IBRAHIM S.ABBAS; NEZAR METAB; HASSENEIN NOOR HADI; KASIM SAKRAN ABBAS; NEJDET ALI; Akram Abd AL- Hussein; Ayat Burhan; Tuka Hassan; Hiba Jalal

karbala journal of pharmaceutical sciences, Volume 6, Issue 10, Pages 0-0

Gentamicin is aminoglycoside antibiotic commonly used for the treatment of
Gram-negative bacterial infection. In many cases, it has been the only effective
therapeutic drug against bacterial strains resistant to other antibiotics, but nephrotoxicity
and hepatotoxicity side effects limit its use. The aim of this study is to investigate the
protective effect of olive oil against gentamicin-induced hepatorenal toxicity in male
albino rats. In this study we used 24 wistar-albino rats and divided them into 4 equal
groups. Each experimental group consisted of six animals. group1,control they were
given normal saline only ,group2,gentamicin 100 mg/kg/day intraperitoneal
(IP),group3,olive oil 5 ml/kg/day (oral administation) ,group 4,gentamicin 100 mg/kg/day
intraperitoneal (IP) and olive oil 5 ml/kg/day (oral administration).Treatments were
administered once daily for 21 days. After 21 days, biochemical and histopathological
analysis were conducted to evaluate hepatoranal toxicity. Serum levels of urea,
creatinine, cholesterol,triglyceride,and activity of AST and ALT were measured.Animals
treated with gentamicin alone showed a significant increase in serum levels of these
markers.Treatment of rats with olive oil showed significant improvement in renal and
hepatic function , presumably as a result of decreased boichemical parameters associated
with gentamicin-induced hepatorenal toxicity.Histopathological examination of the rats
kidneys and liver confirmed these observations. Therefore olive oil may protect against
gentamicin-induced hepatorenal toxicity