ISSN: 7027-2221

Keywords : Mannich bases

Synthesis and characterization of some New Mannich bases and their thione derivatives .

Muhannad A.Mahmood; Ruaa M.Dedan; Wissam K.Jassim; Sahar T.Aday

karbala journal of pharmaceutical sciences, Volume 3, Issue 3, Pages 223-233

N,N'-methylenebis(N-phenylacetamide), N-((2,3-dioxoindolin-1-yl)methyl)-N-phenylacetamide, 2-amino-3-(1-((N-phenylacetamido)methyl)-1H-indol-3-yl) propanoic acid, 2-amino-3-(1-((N-phenylacetamido)methyl)-1H-imidazol-5-yl)propanoic acid, and N-((1,3-dioxoisoindolin-2-yl)methyl)-N-phenylacetamide were prepared by the condensation of acetanilide with paraformaldehyde and secondary amines, and were found to react with phosphours penta sulphide to give N,N'-methylenebis(N-phenylethanethioamide), N-((2,3-dithioxoindolin -1-yl)methyl)-N-phenylethanethioamide, 2-amino-3-(1-((N-pheny lethan ethioamido)methyl)-1H-indol-3-yl)propanoic acid, 2-amino-3-(1-((N-phenylethan ethioamido ) methyl )-1H-imidazol-5-yl) propanoic acid and N-((1,3-dithioxoisoindolin-2-yl)methyl)-N-phenyl ethane thioamide respectively.
The structures of the prepared compounds (1-10) are characterized by C.H.N.S analysis and FT-IR,1H-NMR (for some of them) spectroscopy ,the melting points are reported and the purity of compounds are checked by T.LC.technique.