ISSN: 7027-2221

Keywords : Benzothiazoles


Synthesis and Antibacterial Activity Evaluation of Several New Sulfonamido Naphthalimides Linked to Benzothiazole or Oxadiazole

Ahlam Marouf Al-Azzawi; Ahmad Solaiman Hamd

karbala journal of pharmaceutical sciences, Volume 6, Issue 10, Pages 0-0

In this work several new sulfonamido naphthalimides linked to benzothiazole or oxadiazole
cycles were synthesized via multistep synthesis. The first step involved synthesis of compound [1]
N-phenylnaphthalimide via reaction of aniline with naphthalic anhydride at high temperature in the
presence of glacial acetic acid. In the second step compound [1] was introduced in reaction with
chlorosulfonic acid producing compound [2] 4-(N-naphthalimidyl) phenyl sulfonyl chloride which
inturn introduced subsequently in the third step in reaction with 2-amino-5-substituted-1,3,4-
oxadiazoles producing the target naphthalimides [10, 11] or with substituted 2-aminobenzothiazoles
producing the target naphthalimides [12-16]. Results of antibacterial activity study of the newly
synthesized naphthalimides indicated that they posses high antibacterial activity.