ISSN: 7027-2221

Keywords : Fluvastatin Sodium


Spectrophotometric determination of drug compounds in pure forms and in the pharmaceutical preparations

Qabas Naji Rashid

karbala journal of pharmaceutical sciences, 2017, Volume 8, Issue 12, Pages 1-14

A sensitive, rapid and economical spectrophotometric processes for estimation
of two drugs; methyldopa (MTD) and Fluvastatin Sodium (FLV), by “Sodium 1,2-
naphthoquine- 4-sulfonate (NQS)” as reagent in an alkaline interemediate. These
methods are digested on the forming of “complexes” among these drugs and the
chromogenic reagent (NQS). Orangish-brown colored complex formatted at (pH
12) and λmax. 462 nm for (MTD), and orange colored at (pH 11.7) and λmax. 466 nm
for (FLV). Beer’s Law is obeyed in a concentrations range of (4-40 μg/mL), (16-
64 μg/mL), with molar absorptivity (14.101×104 L/mol.cm), (22.7×104 L/mol.cm),
and correlation coefficient 0.9995, 0.9987, successively, The detection limit and
quantification limit were (1.03×10-1 μg/mL, 3.12×10-1 μg/mL ), and (1.36×10-1
μg/mL, 4.12×10-1 μg/mL ), successively. The suggested methods were prosperity
implement to the estimation of “these drugs” in pure forms and in their
pharmaceutical formulations.