ISSN: 7027-2221

Keywords : poloxamer

Study the Effect of Polymer Types on Preparation and in-vitro Evaluation of β-sitosterol as a Topical Hydrogel

karbala journal of pharmaceutical sciences, 2018, Volume 9, Issue 15, Pages 32-48

Beta sitosterol is a non-cholesterol sterol, or neutral sterol applied locally for
the treatments of acute and chronic ulcers of skin and mucous membranes as well as
post operative wounds. In this work β –sitosterol was prepared as topical hydrogel by
cold mechanical method using different types of gel-forming polymers such as
chitosan (4%, 3%, and 2%) W/W, carbapol (1.5%, 1%, and 0.5%) , and poloxamer
407( 30% and 25%)W/W. Physicochemical properties of all the prepared formulas
were evaluated as a visual inspection, determination of pH, and spreadability, in
addition to an in-vitro drug release.
The obtained results indicated that all the different concentrations of each
polymer gave a percent of drug release profile inversely proportional with the
polymer concentration. F8 which contain poloxamer 407 at 25% produced higher
drug release than other formulas (100% β-sitosterol release withim 3 hrs).
Based on overall result, β-sitosterol can be successfully prepared as a topical hydrogel
using 25% poloxamer as the best prepared formula.البيتاسايتوسترول هو ستيرول غير الكولسترول ، أو ستيرول محايد تطبيقه محليا لعلاج القرحة الحادة
والمزمنة من الجلد والأغشية المخاطية وكذلك الجروح ما بعد العملية. في هذا العمل ، تم تحضير
البيتاسايتوسترول علىشكل هلام مائي موضعي باستخدام طريقة ميكانيكية باردة باستخدام أنواع مختلفة من
1٪ ، و 0.5 ٪) ، و البوليكزامر ، ٪ 2٪) ، الكاربول ( 1.5 ، ٪3 ، ٪ البوليمرات المكونة للهلام مثل الكيتوسان ( 4
%25 ) و مع تركيز مختلف لكل منهما. تم تقييم الخواص الفيزيائية الكيميائية لجميع الصيغ ,%30 ) 407
المعدة على أنها فحص بصري ، وتحديد درجة الحموضة ، وقابلية انتشار ، بالإضافة إلى إطلاق عقار في
أشارت النتائج المتحصل عليها إلى أن جميع التراكيز المختلفة لكل بوليمر أعطت نسبة مئوية من
التي تحتوي على البوليكزامر 407 بنسبة F صورة إطلاق الدواء تتناسب عكسي اً مع تركيز البوليمر. أنتجت 8
25 ٪ الافراج عن المخدرات أعلى من الصيغ الأخرى ( 100 ٪ الافراج مع 3 ساعات).
بناء على النتيجة الكلية ، يمكن تحضير البيتاسايتوسترول بنجاح علىشكل هلام مائي موضعي
25 بتركيز ٪ باعتباره أفضل صيغة محضرة.

Erectile Dysfunction in Diabetic Patients in the Holy Kerbala/Iraq in 2018

karbala journal of pharmaceutical sciences, 2018, Volume 9, Issue 15, Pages 1-10

Erectile dysfunction affects more than 50% of diabetic patients and results in miserable
couple’s life, especially for young adults. Possible predictors are proper therapy and
patient’s compliance with treatment, in addition to the warning signs and symptoms of
sensory neuron and motor deficits. Therefore, this study was conducted to determine the
prevalence of Erectile dysfunction and its predictors among diabetic patients in Kerbala.
Material and methods
The study included a convenient sample of 61 patients with diabetes mellitus type I and II.
They were chosen through a systematic sampling among patients at the diabetes mellitus
clinic at Al Hussein Teaching Hospital in Holy Kerbala /Iraq in 2018. All participants
were interviewed using standard questionnaire. Analysis of data used descriptive and
analytic tools including t-test, chi-square test, logistic regression and structural Equation
modeling through the statistical Package of social sciences and Amos and Excel software
at a significance level of


diabetes mellitus
erectile dysfunction
Autonomic changes
sensory and motor changes
glycemic control.

Effect of water-soluble polymers and cosolvent on with candisartan– cyclodextrin complex solubility


karbala journal of pharmaceutical sciences, 2015, Volume 6, Issue 10, Pages 0-0

Objective: The aim of the study is to find the candesartan celexitile (CC) solubility profile in the
presence of ß-cyclodexrin, poloxamer 188 and PEG 400 and the synergism effect of the cosolvency
of PEG 400 and the solubilizing effect of polymer poloxamer 188 on the drug cyclodextrin
Methods: An excess amount of (CC) was added to 10 mL aqueous solutions containing range
concentrations of either poloxamer 188 (0−0.4% w/v), β-CD (0−1%, w/v) or PEG (0−50%,v/v) at
25±1 ºC separately. The mixtures of aqueous solution were shaken in a thermostated water bath at
25°C ± 2 for 24 h to reach equilibrium. After that, all the suspensions were filtered through 0.22 μm
syringe filter and assayed for (CC) by UV Spectrophotometer at ʎ of 255 nm. Phase solubility
diagrams were plotted with (CC) solubility versus either ß-CD, poloxamer or PEG 400
concentration separately.
Results: It was found that the solubility of (CC) increased with the increasing concentration of
poloxamer188, PEG 400 or ß-CD. The phase solubility curves of (CC) in aqueous solution at 25°C
of ß-CD was of Higuchi’s AL-type confirming the formation of 1:1 complexes. The synergism
effect of poloxamer 188 and PEG 400 on the solubility of (CC) in the presence ß-CD was marked.
The values of stability constants (Ksp) of drug- ß-CD complexes and in the presence of PEG 400 or
poloxamer 188 with 0.4 mg / ml ß-CD were 59.7, 5.8 and 195.8 M-1 respectively. Addition of
poloxamer 188 to the drug-ß-CD complex increase the constant stability while addition of PEG 400
decrease the constant stability of the complex.
Conclusion: The solubility profile of (CC) in the presence of CD followed Higuchi equation
confirming the formation of 1:1complexes of AL-type. The synergism effect of the polymer on the
CC-CD complexes was significant.