ISSN: 7027-2221

Keywords : Biological activity


Synthesis and characterization of new complexes of schiff bases derived from "sulfanilamide" with metal ions Hg+2, Zn+2 and evaluation their biological activity

Rusul.M.Al-kateeb; Safaa A. Al-Samarrai; Malath Kh. Rasheed

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 299-313

A new four Schiff bases synthesized by the condensation of the aromatic amine
compound: 4-amino benzenesulfonamide with the four aromatic aldehyde
compounds: 4-chloroBenzaldehyde, 4-BromoBenzaldehyde, 4-HydroxyBenzaldehyde
and 4-(N,N-dimethyl) aminoBenzaldehyde, Also a complexes of pervious ligands were
synthesized with the metal ions with molarity ratio (1:2) M:L. The synthesized
compounds were characterized by physical and spectroscopic measurements (IR
spectrum and proton NMR spectrum, elemental analysis C.H.N, Molar conductivity).
All the synthesized complexes were formed tetra-coordinate complexes and the
supposed chemical formula of the consequent complexes:[M(L)2Cl2]. The Biological
activity were evaluated for the synthesized compounds against two types of bacteria
E.Coli and S.aureus, most of complexes shown anti-bacterial activity.

Synthesis, Characterization and Study Biological activity of some New 1,3-Oxazepine and 1,3-Diazepine derivatives

Ruaa W. Adam; Ezzat.H.Zimam

karbala journal of pharmaceutical sciences, Volume 5, Issue 7, Pages 195-217

New 1,3-oxazepine and 1,3-diazepine derivatives containing azo group have been prepared. The first step,(O-tolidine) was converted to [3,3`-dimethyl-(1,1`-biphenyl) -4,4`-diyl) bis (diazene-1,2-diyl))bis(naphthalene-2- amine)] Azo O-tolidine[A].by Azotization reaction with naphthyl amine. The second step, amine group of the azo derivative [A] was condensed with different aromatic aldehydes[p-dimethyleaminobenzaldehyde, 4-chlrobenzaldehyde,4-nitrobenzaldehyde,4-bromo benzal dehyde , 4-hydroxy-3-methoxybenzaldehyde] in the presence of absolute ethanol to give new azo Schiff bases derivatives [B-F] respectively. Then, the resulting imines derivatives [B-F] were reacted with maleic anhydride and phathalic anhydride in dry benzene to give new 1,3-oxazepine-4,7-dione ring derivatives [Ba-Fa] , [Bb-Fb] , all these compound reaction with sulphadiazene to producte 1,3-diazepine-4,7-dione ring derivatives [Ba1-Fb2]. Also study the Biological activity to this derivatives ; All prepared compounds were characterized by melting points and FT.IR spectroscopy, some of them are characterized by 1H-NMR spectroscopy and C.H.N analysis.

Synthesis and study the Biological Activity of some new bis Maleimide derivatives containing 1 ,3 ,4- Oxadiazole ring

Ahmad S.H. AL- Janaby; Khalid M.M. AL-Janaby; Fawzi H.J. AL-Obaidy

karbala journal of pharmaceutical sciences, Volume 4, Issue 5, Pages 149-169

This paper contains the synthesis of some new bis heterocyclic compounds starting from the esters of bis carboxylic acid which then converted to its hydrazide [1-5] then to bis1,3,4-Oxadiazole derivatives [6-10] beside bis maleamic acid derivatives [11-15] and finally with bis maleimides [16-20] .
Preparing of bis ester by usual esterification of substituted bis aliphatic carboxylic acid with absolute ethanol in acidic medium , then has converted to its substituted bis aliphatic carboxylic acid hydrazide by reacting it with hydrazine hydrate . The derivatives bis-1,3,4-Oxadiazole have synthesized by cyclization of bis aliphatic carboxylic acid hydrazide with 4- amino benzoic acid in presence of phosphoric acid 85% .
So ,the bis- maleamic acids have been synthesized by the reaction of compounds [6-10] with maleic anhydride in diethyl ether. Also bis maleimides are synthesized by cyclization of bis maleamic acids derivatives by using acetic acid anhydride and anhydrous sodium acetate. The synthesized compounds were identified by spectral methods UV,FT-IR and H1- NMR beside melting point and the purity was determined by using ( TLC ) and some of its physical properties were measured . Some of these compounds are tested against four strains of bacteria ( Staph. aurease , E. coli ,Sal. thph and Ps. aeruginosa)

Extraction, Identification and Antimicrobial Activity of Some Phenolic Acids As Antioxidants in Teucrium polium Plant

Sajda Abbas; Salam A. H. Al-Ameri; Muna Mahmoud

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 179-188

A direct solvent extraction was used for the extraction of aerial parts of local medicinal plant Teucrium polium using methanol ,ethanol, iso-propanol, butanol, chloroform, acetone , ethyl acetate, and hexane. The total phenolic contents of extracts was determined using Folin-Ciocalteu method , the results shows that the highest extraction was obtained by methanol which was found to be equal to 100.144 mg/ g of dry plant. HPLC was employed to identification phenolic acid content especially Gallic acid in Teucrium polium extract with each solvent, The results showed that the highest extraction was obtained equals to 48.07% by methanol followed by acetone and ethanol, also the results shows that the n- hexane give the lowest extraction 4.27%, also butanol with iso-propanol extract contain the large number of phenolic acid contents. The accuracy and precision of this method were determined by preparing laboratory samples of Gallic acid , the results show absolute error ranging from ±0.3 to ± 1.5 , relative errors ranging from ±0.375 to 1.87 % , the standard deviation equal to 0.48 and the relative standard deviation did not exceed ±0.478 %,the standard deviation of the mean was 0.215. The antimicrobial activity of methanolic extracts of local medicinal plant Teucrium polium life samples from Dehok and Al-Kut were examined for their antimicrobial potentials against selected test bacteria and fungi, Aspergillus Niger , Aspergillus parasticus , Staphylococcus aurous positive, Staphylococcus aurous negative, Streptococcus , Escherichia coli and Cladosporium. The present results showed that all the extracts posses good antimicrobial activity against selected test bacteria and fungus. The present results therefore offer a scientific basis for traditional use of Teucrium polium for the treatment of bacterial and fungal infections.