ISSN: 7027-2221

Keywords : Antihyperglycemic


The antihyperglycemic and antihyperlipidemic effect of ethanolic extract of Apium Graveolens (celery) in Streptozocin/ high fat diet induced hyperglycemic mice.

Alaa H. Abbas; Abdulkareem H. Abd; Shihab AbdulRhman; Ibrahim S. Abbas

karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 10-28

In spite of the drugs available for the treatment of diabetes and high blood lipids but still accompanied by undesirable side effects, and so a wide attention and tendency for herbal and poly herbal treatment because of the lack of side effects, and low cost and accessibility.
Celery seeds, also known scientifically as Apium graveolens belong to the plant family Apiaceae . Analysis of the active ingredients of the ethanol extract of celery seeds proved the presence of different compounds, including terpenes and fatty acids, but fatty acids were the largest proportion of the rest of the substances that were examined through GC-MS.
The aim of the current study is to verify the effectiveness of ethanolic extract of A. graveolens in reducing hyperglycemia and high lipids in hyperglycemic mice .
Fourty male mice were used in the current study and mice were divided into 4 equel groups. . Group-1 (control) received distilled water (50µl ) orally and standard diet. Group-2 (drug control) orally and injected with STZ (150 mg/Kg) intraperitonially and received distilled water (50µl per day) orally with HFD . Group-3 injected with STZ and received glyburide (p.o) 0.5 mg/kg per day as standard drug with HFD for 28 days . Group-4 injected with STZ and received ethanolic extract of celery seed (400 mg/kg) per day by gastric lavage as well as HFD.
After the treatment was completed, blood samples were collected for analysis and isolation of liver and pancreas tissue for the histological examination.
The ethanolic extract of A. graveolens showed a significant decreasing in the level of blood glucose, lipid profile , serum (C-peptide) , improved (GSH), and reduction in level of MDA when compared with untreated group. The presence of variety of active consistuents in A. graveolens like flavonoids , turbines and unsaturated fatty acids may be the reason for the antihyperglycemic and antihyperlipidemic effects.