ISSN: 7027-2221

Keywords : glutathione peroxidase

Evaluation of Lipid Peroxidation ,Level of Selenium and Enzymatic Antioxidant Activity in Woman During Pregnancy and Abortion at First Trimester

Rana M. Hameed

karbala journal of pharmaceutical sciences, Volume 3, Issue 3, Pages 234-240

Background:Spontaneous abortion, or miscarriage, is defined as the loss of a clinically recognized pregnancy that occurs before 20 weeks of gestation; early miscarriage occurs prior to week 12 while late spontaneous abortion occurs between weeks 12 and 20.abortion is the termination of pregnancy by the removal or expulsion from the uterus of a fetus or embryo .Human chorionic gonadotropin or human chorionic gonadotrophin (HCG.) is a glycoproteinhormone produced during pregnancy that is made by the developing embryo after conception and later by the syncytiotrophoblast (part of the placenta). the trace mineral selenium is an essential component of the selenoproteins,.Malondialdehyde (MDA) is a major breakdown product split off from lipid peroxidation and can be used to assess the degree of lipidperoxidation . Glutathione and Glutathione peroxidase (G-PX) and superoxide dismutase (SOD) are the main enzymes responsible for the detoxification of superoxide anion andrequired for normal health and reproduction. Total antioxidant activity( TAA )its compounds play an important role as ascavenge free radicals such as peroxide, hydroperoxide or lipid peroxyl and thus inhibit the oxidative mechanisms thatcan lead to pathological conditions like miscarriage
Aim: was to assess whether serum MDA, serum selenium, serum HCG, serum GSH and G-PX, serum total antioxidant TAA , and serum SOD levels altered during early abortions at first trimester and comaper the resulte with healthy pregnant as controls Material/Methods: A group of pregnant women at first trimester gestation age with spontaneous abortion (n=40) and a control group of healthy pregnancies with similar characteristics (n=25) were included. Serum MDA levels, serum selenium, serum HCG, serum GSH and G-PX, serum total antioxidant TAA , and serum SOD levelswere determined and compared among the groups. Results: Characteristics, including maternal age, parity, gestational age, serum total protein, serum albumin, and serum lipid profi le, were similar across the groups. Abortion in first trimester was associated with increased mean serum MDA,GsH levels and theselenium serum concentrations in women with miscarriage were significantly lower as compared to those in women with normal pregnancyandThe glutathione peroxidase activity ,SOD ,TAA, HCG were reduced significantly in women with miscarriage.Conclusions: Increased lipid peroxidation and inhibition of SOD,G-Px ,TAA activity and reduced selenium concentration might be involved in abortions and expulsion of fetoplacental material out of the uterine cavity and may play an important role in the aetrology of spontaneous abortion