ISSN: 7027-2221

Keywords : Asthma


Correlation between Endogenous Vitamin D Status and Body Mass Index in Asthmatic Patients Receiving Adjuvant Vitamin D3 Supplement

RASHA SAADI ABBAS; MANAL KHALID ABDULRIDHA; MOSTAFA ABDALFATAH SHAFEK; HADEEL DELMAN NAJIM

karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 106-121

Background: Most studies showed that the incidence of asthma is frequently associated with increased body mass index (BMI), vitamin D deficiency has been proposed as a risk factor that could explain a significant proportion of increased pattern of asthma prevalence. This study was aimed to track a correlation between body mass index and vitamin D status effect on asthma control in asthmatic patients.
Patients and Methods: This is a prospective randomized -controlled open-label interventional study to evaluate effect of vitamin D3 on asthma control and it's correlation with body mass index in asthmatic patients who are allocated into two main groups: Group 1: Include 20 patients who have diagnosed with asthma are assigned to receive conventional therapy for asthma according to disease stage and severity for three months period. Group 2: Include 24 patients who have diagnosed with asthma are assigned to receive conventional therapy for asthma according to disease stage and severity plus 2000 I.U vitamin D3 fast dissolve mini tablet (Natrol, USA) for three months period. Serum 25-OH vitamin D level, Body mass index (BMI), asthma control test (ACT) scoring system was measured both initially and after three months treatment.
Results: A highly significant improvement in asthma control found in patients after 3 months treatment with vitamin D3 supplement compared to pre treatment level (P<0.01), and was found significantly that among the 10 (42%) obese patients in group 2 with vitamin D deficiency, 6(25%) patients gained vitamin D insufficiency and 2(8%) patients gained vitamin D sufficiency after supplementation with vitamin D3 (P<0.01). After treatment body mass index inversely correlated with vitamin D level in patients receive conventional therapy, meanwhile in patients with vitamin D3 supplement the change in the body mass index after vitamin D3 treatment was parallel to the improvement in endogenous vitamin D level. Also the reduction in the body mass index after vitamin D3 treatment produce a positive correlation with asthma control test, though no significant (P>0.05). No direct correlation was found between endogenous vitamin D level and asthma control test in both study groups.
Conclusion: After vitamin D3 supplement in the current study, the change in the body mass index produce improvement in endogenous vitamin D status parallel to the change in the body mass index and markedly improvement in asthma control. Also the reduction in the body mass index after vitamin D3 treatment was positively correlated with asthma control.

The Role of Interleukines in Asthmatic Patients

Muhamed Salih Mahdi; Hassan A.Al-Saadi

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 42-47

Background: Asthma is a chronic inflammatory disease of the airways because body exposure to foreign materials that stimulate immune response characterized by secretion of cytokines from inflammatory cells.
Objective: Diagnosis of asthma to detect about IgE,IL 1B,IL 2IL 8,,IL10 ,and IL12 in patients clinically suspected .
Patients and Methods:50 blood samples out patients were collected in a labeled 5 ml tubes,aged (26 years to 58 years ) were tested by Enzyme Linkined Immuno Sorbant Assay to detect IgE,IL 1B,IL 2IL 8,,IL10 ,and IL12 were carried in Al-Hussein Hospital in Kerbala ,during the period from May to Augest 2010.
Results:50 patients were evaluated for asthma and correlation between IL 1B,IL 2,IL 8,IL 10 ,IL 12 values (20,76,62,44,76)% respectively and IgE value (50)%.Increasing values of IL2,IL 8,IL 10,IL 12 (36,26,24,32)%respectively at ages(37-47)years were led to decreased IgE value(10%),and IL 2,IL 8 values were (24,22)% respectively comparion with IgE(10%).
Conclusions: Importance studying factors( IL 1B,IL 2,IL 8,IL 10 ,IL 12) in diagnosis of Asthmatic patients after clinically diagnosis .