ISSN: 7027-2221

Keywords : Diabetes

Effect of phenolic compounds extract of S. melongena peels on Sugar levels and biochemical parameters in alloxan-induced Diabetic rats

Yasmine H. Jassim; Ayad F. Palani; Atallah B. Dakeel

karbala journal of pharmaceutical sciences, 2016, Volume 7, Issue 11, Pages 202-209

Diabetes mellitus is a serious complex chronic condition that is a major problem of health
worldwide. Recent studies focused on the ability of phenol compounds in the treatment of
diabetes mellitus and its complications. In the present study, phenol compounds of Solanum
melongena peels were extracted and diagnosed using HPLC, and the extract administrated to
alloxan induced diabetic rat. The aim of this study is to investigate the effect of phenol
extracts of S. melongena peels on sugar, lipid and liver enzymes in alloxan induced diabetes
in rats. Serum glucose level, lipid profile, GOT and GPT enzymes were estimated and results
were statistically calculated by ANOVA and the differences were considered significant at p
value ≤0.05. Results showed that the administration of phenols extract decreased the glucose
level in the phenols administrated diabetic rat. Also phenols extract decreased cholesterol,
triglyceride and LDL level, and increased serum HDL level diabetic rat. The phenol
compounds also showed the ability to detoxify liver via lowering GOT and GPT enzymes in
phenols administrated diabetic rat.