Keywords : VLDL
High Fat Diet Induce Hyperlipidemia Incidences With Sever Changes in Liver Tissue of Male Albino Rats: A Histological and Biochemical Study
karbala journal of pharmaceutical sciences,
Volume 4, Issue 6, Pages 21-32
This study was designed to investigate the effects of high fat diet on liver tissue as well as biochemical changes of lipid profiles of hyperlipidemic and normolipidemic rats which treated with atorvastatin before and after induction of hyperlipidemia by feeding the rats with high fat diet, the result showed:
There was high significant increase(p<0.0005)in TC,TG,LDL,VLDL , and AI, but there was high significant decrease in HDL in rats fed on HFD for seven months if compared with negative control group, while atorvastatin treatment caused high significant decrease(p<0.0005)in lipid profile parameters after three months of treatments if compared to positive control group. Atorvastatin treatment result in high significant decrease (p<0.0005,p<0.005)in TC,TG,LDL,VLDL, and AI in normolipidemic rats as compared with negative control group.
The histological sections of liver were revealed presence of severe histopathological changes which classified into grades between 0-4. The most severe changes were in liver sections of hyperlipidemic rats which consist: infiltration of lipids in micro, mid, and macro vascular steatosis, while some livers were observed to contain onset of fat sacs, damage of unique radial appearances of hepatocytes in hepatic lobule, lymphocytes infiltration, congestion also observed in some liver section of these animals, whereas the histopathological changes in livers of normolipidemic rats which treated with atorvastatin were less severity as compared with positive control rats these changes included: sever lymphocytes infiltration especially around central portal vein, pyknotic nuclei, severe congestion and loss radial appearances of hepatocytes also there was dilatation of central portal vein and some bile ducts, while atorvastatin treatment reduce the effects mentioned in some hyperlipidemic individuals.