ISSN: 7027-2221

Keywords : Chlorpheniramine Maleat


Derivative spectrophotometric method for estimation of Chlorphinramine Maleat in pure and its formulation Phenadone

Al Samaraee; E.Th

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 179-191

A simple, sensitive, economic, accurate and precise first (D1) and second (D2)
derivative spectrophotometric method has been developed for determination of
Chlorpheniramine maleate in pure and syrup form . The method obeys Beer’s Law in
concentration range of 5-45μg/ml employed for evaluation . The quantitative
determination of the drug was carried out using the first and second derivative values
by measured ; peak to base line at ( 274 nm and 236 nm for first derivative) and (282
nm , 262 nm and 241 nm for second derivative ) , peak to peak at ( 274 nm – 263 nm
for first derivative ) and ( 282 nm-262 nm and 262 nm – 241 nm for second
derivative ) and peak area at ( 290 nm – 264 nm and 264 nm – 226 nm for first
derivative ) and at (304 nm -274 nm , 274 nm – 254 nm , 254 nm – 232 nm for second
derivative ) in 1:10% absolute ethanol: distal water . The results of analysis were
validated by recovery studies . The recovery and RSD was ( 102.916-95.555 % ) and (
0.751 – 0.006 %) respectively . The proposed method can be used for the routine
quality control testing of the marketed formulations .