ISSN: 7027-2221

Keywords : Quasi


Formulation &invitro evaluation of clarithromycin floating microsponge capsule

Jenan m. Mohsin al mosawi; Alaa Abdul- Razzaq; Hasanain Shakir Mahmood

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 27-35

Objective: The aim of this study is to formulate microsponge of clarithromycin capsule
dosage form and evaluate the release profile in comparing with marketed clarithromycin
(Clamycin)
Methods: clarithromycin microsponge was prepared by quasi-emulsion solvent diffusion
method by using polymers Eudragite RL100 in organic solution as internal phase and
aqueous solution of polyvinyl alcohol as external phase. The compatibility of the drug
with formulated components was established by Fourier Transform Infra-Red (FTIR)
spectroscopy. The prepared microsponge powder was evaluated for angle of repose,
Carr's Index ,particle size, floating time production yield, drug loading efficiency of
microsponges and release profile in comparison with marketed drug.
Results: Formulation F4 with a ratio 8:1 drug to polymer, and 0.25% polyvinyl
pyrrolodine solution was the best formulation showing the highest degree of sustained
release that was 79.59% at the end of 12 hours with a floating time capsule 12 hr.
Eudragit RL 100 could control drug release in stomach.

Formulation and evaluation of clarithromycim oral microspong

Jenan m. Mohsin al mosawi; laith hamza samein; alaa abdul- razzaq

karbala journal of pharmaceutical sciences, Volume 6, Issue 9, Pages 114-123

Clarithromycin is a broad-spectrum antibiotic and extensively absorbed orally. It is be used in the
eradication of H. Pylori infection combined with an acid suppressing agent. The purpose of this study
was to develop controlled release clarithromycin floating micro sponges for gastro retentive drug
delivery. The micro sponge’s formulations were prepared by quasi-emulsion solvent diffusion
method employing eudragit RS 100 as a polymer and poly vinyl alcohol (PVA) as a surfactant.
The compatibility of the drug with formulation components was established by Fourier
Transform Infra-Red (FTIR) spectroscopy. The prepared microsponge were evaluated for angle
of repose, Carr's Index ,particle size, floating time production yield, drug loading efficiency of
micro sponges. Shape and surface morphology of the micro sponges were been examined using
scanning electron microscopy. formulation F5 with drug to polymer ratio 8:1,10 ml of internal
phase volume (ethanol: dichloromethane) and 0.25%pva solution was the best formula
showing the highest degree of sustained release that is 79.59% at the end of 12 hours with
floating time for 12 hr. Eudragit RS 100 could control drug release in stomach.