ISSN: 7027-2221

Keywords : smoking


Study the effect of physical exercises to decrease the dangerous of smoking By estimated some serological biomarkers

Alaa Abd-Alhasan Hamdan

karbala journal of pharmaceutical sciences, Volume 8, Issue 12, Pages 131-142

the smoke of cigarette consists of many harmful chemicals materials , such as , carcinogenic and free radicals, thus it cause damage for many organs of the body, also it affect on the lipid concentration of plasma. In this study we estimated the effect of exercises to decrease the dangerous of smoking by determination the level of lipid profile, TAC , Hs-CRP, MDA, AST and ALTtotal protein, in two groups of smokers one with exercise and the other is not, this study estimated the effect of sport in decrease the dangerous of smoking. Results showed that the level of lipid profile (total cholesterol, TG, HDL-C, LDL-C and VLDL-C) have significant differences in all groups of smokers as comparison with control. There is a parallel increased in the level of plasma lipid as increase in number of cigarette per day. except leveles of HDL-C which increased with decrease of duration and intensity of smoking. The liver function test ALT, AST ALP, STB were significant deference at (P value≤0.05) when compare both groups A1 and A2 with control. Total protein, albumin, globulin, have significant deference when compare both groups A1, B1 and A2, B2 with control. TAC, Hs-CRP, MDA have significant deference when compare both groups A1, B1 and A2 with control.

Intercellular adhesion molecules -1 (ICAM-1) and Vascular cell adhesion molecules-1 (VCAM-1) in hypertensive patients suffering from bacterial UTIs .

Nidhal abdul Mohaimen; Arif Sami; Zainab Thamer Showait Al-assady

karbala journal of pharmaceutical sciences, Volume 4, Issue 5, Pages 56-68

Leukocyte binding to cellular adhesion molecules (CAMs) on the surface of vascular endothelial cells appears to be one of the earliest events in the atherosclerotic process. In this study the concentration of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on lymphocytes were evaluated during vascular disease like hypertension . In addition level of CAMs in hypertensive patients in response to other factors like sex, aging , smoking , anti hypertension drugs treatment (mainly with some β-blockers(propranolol) or ACE inhibitors(captopril)) and UTIs were also measured . As compared to controls mean of ICAM-1 and VCAM-1 were significantly elevated in hypertensive subjects. VCAM-1 was significant in male compared to female . Significant positive correlation was observed of VCAM-1 level in relation to ageing , Smoking and in hypertensive patients suffering from UTIs. While the level of both ICAM-1 and VCAM-1 was found to be decreased upon anti hypertension treatment with either β-blocker or ACE inhibitor decreased.

Effect of gender , aging , smoking and urinary tract infections on level of CD4+ T lymphocytes in hypertensive patients treated with propranolol and captopril drugs

Nidhal abdul mohaimen; Arif sami; Zainab Thamer showait al-assady; Ali jalil ali

karbala journal of pharmaceutical sciences, Volume 4, Issue 5, Pages 69-80

Forms of adaptive response may be useful markers of endothelial activation and local or systemic inflammation. In this study the CD4+ T lymphocytes were evaluated during vascular disease like hypertension and the effect of other factors like sex, aging , smoking , anti hypertension drugs treatment (mainly with some β-blockers or angiotensin converting enzyme inhibitors) and urinary tract infections on expression of the CD4+ T lymphocytes were also studied . The results showed that mean level of CD4+ T lymphocytes was increased in hypertensive patients (p≤ 0.01) and this increase is more in female compared to male . Level of CD4+ T lymphocytes was significantly elevated in hypertensive subjects with age group of 30-40 years and the level started to decreased with aging. However, upon treatment with antihypertensive drugs (mainly β-blocker or angiotensin enzyme inhibitors) the level of CD4+ T lymphocytes was reported to decreased . CD4+T lympho-cytes level was significantly increased in hypertensive smoking patients(P ≤ 0.01) and in patients suffering from urinary tract infections (UTIs) .