ISSN: 7027-2221

Keywords : Artichoke

Hepatoprotective activity of Artichoke (Cynara scolymus) against Paracetamol toxicity in female rats

Msc.Amal umran musa; Msc. Shatha Hussein kadhim; Msc. Zahraa abed al- kreem; Msc. Moayad Mijbil ubaid

karbala journal of pharmaceutical sciences, Volume 7, Issue 11, Pages 36-43

Hepatotoxicity is an acute adverse effect of paracetamol overdose which could be fatal, so in
this research we studied the effect of paracetamol on liver enzymes (GPT, GOT, total protein,
glucose, bilirubin) of female rats that drenched Artichoke. twenty laboratory female rats housed in
plastic cages in animal house at university Karbala of / college of pharmacy , the animals divided
randomly into four groups ,(G1 control, G2 drenched with 500 mg/kg Artichoke and 500 mg/kg
paracetamol, G3 drenched with 500 mg/kg paracetamol ,G4 drenched with 500 mg/kg Artichoke ) ,
the present study found the ability of Artichoke to protect liver enzyme against the poisonous effect
of paracetamol by reducing the higher value of GPT,GOT, glucose, and evaluated the lower value
of bilirubin and total protein causing by paracetamol. Histopathological changes in liver were
greatly reduced on animals treated with artichoke and paracetamol when compared with the
paracetamol group .However, animals treated with paracetamol showed severe congestion in central
vein and there is inflammatory cell and degeneration in hepatocyte enlargement in sensoides and
necrosis and odema.