ISSN: 7027-2221

Keywords : Hepatotoxicity


The effect of olive oil (Olea europaea) on ibuprofen induced hepatotoxicity in female rats

Mohammed Talat Abbass; Rabab Murtadha Abed; Nazar Jabar Metab

karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 178-187

Ibuprofen, a propionic acid derivative, is one of the most commonly Non-steroidal anti-inflammatory drugs, which are among the most frequently prescribed medications worldwide. The aim of this study is to investigate the protective effect of olive oil against ibuprofen-induced hepatotoxicity in female albino rats. In this study we used 24 female white rats and divided them into 4 equal groups. Each experimental group consisted of 6 animals. Group1,control they were fed on diet and water without any treatment ,group2, ibuprofen given at dose 40 mg/kg/day orally by gastric tube for 30 days, group3,olive oil 2 ml/kg/day (oral administation), group 4, ibuprofen at dose of 40 mg/kg/day and olive oil 2 ml/kg/day (oral administration).Treatments were administered once daily for 30 days. After 30 days, biochemical and histopathological analysis were conducted to evaluate hepatotoxicity. Serum levels of albumin, total proteins, and activity of AST, ALP, ALT and total bilirubin were measured. Animals treated with ibuprofen alone showed a significant increase in serum levels of ALT, AST and ALP and significant decrease in albumin and total proteins. Treatment of rats with olive oil showed significant improvement in hepatic function , presumably as a result of decreased boichemical parameters associated with ibuprofen-induced hepatotoxicity. Histopathological examination of the rats liver confirmed these observations. Therefore olive oil may protect against ibuprofen-induced hepatotoxicity.

Effect of Morin on Isoniazid and Rifampicin Induced Hepatotoxicity in Rats

Mohammed Mustafa Hashim Zayni; Mohammed Talat Abbas

karbala journal of pharmaceutical sciences, Volume 4, Issue 4, Pages 32-39

The first line drugs used for tuberculosis therapy are isonizid and rifampicin (INH
&RIF) and they are associated with hepatotoxicity, for this reason we aimed to study
the protective effect of morin on the hepatotoxicity induced by the tow
antituberculosis agents given together.
To reach study object 24 female Wistar albino rats 220-250 g were divided into four
groups, each group consisted of six animals received standard diet and tab water along
the 21 days which is the experimental period. The control groupleaved without
treatments while the morin group, rats were treated with 30mg/kg/day morin via
gavage along the days of the experiment. INF-RIF group, rats were treated with 100
mg/kg/day INH-RIF by intraperitoneal injection method for 21 days. INF-RIF and
morin group, rats were treated with 100 mg/kg/day INH-RIF plus morin with a dose
of 30 mg/kg /day via gavage along the experimental period.
The results had a significant increase in the activity of alanine aminotransferase,
aspartate aminotransferase and malondialdehyde level and significant decrease in the
activity of superoxide dismutase, glutathione peroxidase, glutathione s-transferase and
catalase in animal groups treated with INH and RIF as compared to control groups.
However, supplementation of INH-RIF intoxicated rats with morin ameliorated the
antituberculosis drugs adverse effects as evidenced by a significant decrease in
alanine aminotransferase, aspartate aminotransferase activity and malondialdehyde
level and significant increase in superoxide dismutase, glutathione peroxidase,
glutathione s-transferase and catalase. We concluded that morin have a potential to
protect the liver from INH and RIF toxicity.