ISSN: 7027-2221

Keywords : Synthesis


Synthesis and Biological testing of new 1,3- oxazepine derivatives of pharmaceutical interest

Khalid.M .Mohamad Al-janaby; Ali.I.Mustafa.AL-Jobory

karbala journal of pharmaceutical sciences, Volume 5, Issue 7, Pages 21-30

Some derivatives of 1,3 oxazepine – Schiff bases have been synthesized by the reaction of some aromatic aldehydes with N-phenyl azo aniline to synthesis of the compounds ,2-(p-phenyl azo)-1,4-phenylene aniline(1-6) ,and these compounds (1-6) were reacted with phthalic anhydride to obtain derivatives of 1,3- oxazapine. The chemical structures of the products were characterized by (IR ,and 1H NMR) and biological activity for some of these compounds were studied against three kinds of bacteria

Synthesis and Chemico-Biological Studying of Various Organic Compounds

Nagham Mahmood Aljamali; Hameeda Eedan Salman

karbala journal of pharmaceutical sciences, Volume 4, Issue 4, Pages 73-84

In this work ,synthesis of variety of organic compounds [1-6] such as thiol compound , oxazepine (oxazepam) ,diazepine (diazepam) ,macrocyclic Schiff base ,azo compound which contains electron donating group and azo compound is containing electron with drawing group and identification of their structures by {(C.H.N) microanalysis , 1H-NMR spectra and (FT-IR) – spectrum } and study of their biological activities , the data obtained give good supported for synthesized compounds[1-6]

Preparation and characterization of some new heterocyclic compounds with evaluating of its biological activity

Wissam K. Jassim

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 241-256

A series of compounds of p-Nitro ethyl benzoate [2],p-Nitro benzoic hydrazide [3], 1-phenyl-4-(p-nitrophenyl) thiosemicarbazide [4], 3-mercapto-4-phenyl-5- (p-nitro phenyl)-1,2,4- Triazole[5], 3-hydrazino -4-phenyl-5- (p-nitro phenyl)-1,2,4- Triazole [6], 3-( substituted benzylidene hydrazine)-4-phenyl-5- (p-nitro phenyl-2-yl)-1,2,4-triazole [7] and [8], 2-(substituted aryl)-3-(p-nitrophenyl)-2-yl)-2,3-dihydro-1,3-oxazpine-4,7-dione.[9] and [10], 2-(substituted aryl)-3-(p-nitrophenyl)-2-yl-2,3-benzo-1,3-oxazpine-4,7-dione [11] and [12], 2-(substituted aryl) –tetrazolo-1-yl)-[(3-hydrazino-4-phenyl)- 5-p-nitrophenyl)1,2,4-triazole ] [9], 2-substituted aryl-3~-[3-hydrazino—4-phenyl-5-(p-nitrophenyl)1,2,4-triazole]-2-yl-thiazolidin-4-one [15] and [16]. 2-(substituted aryl) –3-[3-hydrazino—4-phenyl-5-(p-nitrophenyl)1,2,4-triazole]-2-yl-imidazolidin-4-one [17]and [18] were prepared and the chemical structures of these compounds were characterized by FT-IR , 1H-NMR for some of them Uv/vis spectra , C.H.N analysis ), melting points and the purity was checked. Biological activity of these compounds was evaluated.

Synthesis , characterization of some new heterocyclic compounds and evaluating their biological activity

Fawzi H. Jumaa; Shaymaa A. Suood; Ibtisam K.Jassim

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 167-178

Abstract
This work involves synthesis of some heterocyclic compounds including 2- amino-5-[(3,5-dimethyl phenoxymethylene)-1,3,4-thiadiazole [3]. 2-( substituted benzylidene)-1,3,4-Thiadiazole -5- (3,5-dimethyl phenoxy methylene [4,5]. 2- [ p-nitro or p-dimethyl amino phenyl]-3- (1,3,4-thiadiazole-2-yl-5-{3,5-dimethyl phenoxymethylene}) imidazolidine-4-one [6,7]. 2-[ p-nitro or p-dimethyl amino phenyl]-3- (1,3,4-thiadiazole-2-yl-5-{3,5-dimethyl phenoxymethylene}) thiazolidin-4-one [8,9].
The prepared compounds were characterized by spectral methods FT-IR ,1H-NMR and some physical properties with evaluation of their biological activity.

Synthesis, Characterization and Evaluation of Antibacterial Activity of Several New 1,8-naphthalimides Containing Benzothiazole Moiety

Ahmed Sulaiman; Ahlam Marouf Al-Azzawi

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 111-123

A series of new 1,8-naphthalimides linked to benzothiazole moiety were synthesized by following two different strategies:
The first one involved direct reaction of equimolar amounts of substituted-2-aminobenzothiazoles with 1,8-naphthalic anhydride in glacial acetic acid under reflux at high temperature for eight hours. The second strategy based on Gabrial synthesis including preparation of unsubstituted-1,8-naphthalimide via refluxing of naphthalic anhydride with ammonium hydroxide at high temperature for six hours then the resulted 1,8-naphthalimide was treated with alcoholic potassium hydroxide to afford naphthalimide potassium salt and this in turn was introduced in the reaction with 2-(2-chloroacetylamino)benzothiazoles (which were prepared via treatment of 2-aminobenzothazoles with chloroacetyl chloride) producing new series of N-(2-acetamido substituted benzothiazole-2-yl)-1,8-naphthalimides.
Structures of the prepared compounds were confirmed by depending on FTIR, 1H-NMR and 13C NMR spectral data which were in agreement with the proposed ones. Finally antibacterial activity of some of the prepared new cyclic imides were evaluated against two types of bacteria and the results showed that the most of the tested imides posses good biological activity against these organisms.

Synthesis and characterization of heterocyclic compound derivatives from 2-azo benzothiazole have possible biological activity

Maha.K.Mahmmod; Entesar.O. AL-tememi

karbala journal of pharmaceutical sciences, Volume 2, Issue 2, Pages 81-96

Reaction of different substi tuents of 2-azobenzothiazolyl 4-phenols (I) with ethyl 2-bromo propionate to produce the derivatives (II) that react with thiosemicarbazide gave N-substituted thiosemicarbazide (III) also react with semicarbazide and which gave N-substituted semicarbazide (IV). The 1,2,4-triazole derivatives (V) and 1,3,4- thiadiazole derivatives (VI) were prepared by the cyclization of N-substituted thiosemicarbazide (III) with base and with concentrated sulphuric acid respectively . The 1,3,4-oxadiazole derivatives (VII) were prepared by the cyclization of N-substituted semicarbazide (IV) with acid. the new compounds were established on the basis of IR, 1H NMR and UV spectral data.