karbala journal of pharmaceutical sciences

In this study some new compounds have been synthesized including preparation of some different Schiff bases (1-5) from the reaction of aromatic amines with terphthadehyde in absolute ethanol and converted into derivatives of 1,3-Oxazepine (of ring closure reaction (2 +5) of Schiff bases with maleic anhydride in benzene (6-10) besides the 1,3- Imidazolidenon (11-15) and evaluation of biological activity for some of them. The prepared compounds were characterized by FT-IR spectra and 1H-NMR spectra for some of the prepared compounds besides the determination of their melting points and TLC (Thin Layer Chromatography.

This search includes preparation p-methoxy benzoyl hydrazine (II2) from the reaction between p-methoxy ethyl benzoate (I1) with hydrazine haydrate with the existence of ethanol absolute , then they were converted to hydrazine derivatives with different substituents (III3-6) through the reaction with aromatic benzaldehyde with out using a solvent under thermal fussion . Compounds of 1,3-oxazepine-4,7-dione (IV7-10) have also been prepared by ring closer reaction through the treatment of the prepared hydrazones (III3-6) and maleic anhydride ,The structure of the synthesis compounds was confirmed by FT-IR and 1HNMR spectral data , as the physical means ,the biological activity was studied againt two types of bacteria.

Some derivatives of 1,3 oxazepine – Schiff bases have been synthesized by the reaction of some aromatic aldehydes with N-phenyl azo aniline to synthesis of the compounds ,2-(p-phenyl azo)-1,4-phenylene aniline(1-6) ,and these compounds (1-6) were reacted with phthalic anhydride to obtain derivatives of 1,3- oxazapine. The chemical structures of the products were characterized by (IR ,and 1H NMR) and biological activity for some of these compounds were studied against three kinds of bacteria