ISSN: 7027-2221

Keywords : Saccharin

Synthesis of some saccharin derivatives containing 1,2,3-triazoline ring

Mustafa K. Shneshil

karbala journal of pharmaceutical sciences, Volume 8, Issue 12, Pages 42-48

Some of 1,2,3-triazoline containing compounds were prepared starting from sodium saccharin. The later was reacted with allyl chloride forming allyl saccharin, then reacted with n-heptyl azide to give compound (1) named as (N-((1-n-heptyl-1,2,3-triazolin-4-yl)methyl) saccharin. Compound (1) was hydrolyzed under strong basic conditions to form the carboxylic acid derivative (2). Compound (2) reacted with ethanol to produce the ester derivative (3), the ester derivative (3) reacted with hydrazine to form the hydrazide derivative (4). Compound (4) was reacted with propargyl chloride to form (5). Compound (5) finally reacted again with n-heptyl azide to form (6). The compounds were identified using the analytical and spectral methods shown in the work. The compounds were tested for their biological and antioxidant activity; some compounds were active and other was not.