karbala journal of pharmaceutical sciences

Background: Benign prostatic hyperplasia (BPH) is a prevalent problem among older men . There is controversy about the risk factors that contribute to the development and aggravation of BPH, diet and obesity may have a major role in the development of BPH. This study investigate body mass index (BMI) as a marker of obesity, leptin level, and lipid profile in correlation with the prostate-specific antigen PSA in symptomatic BPH Iraqi patients.
Patients and Methods : Randomly selected twenty patients newly diagnosed with BPH visited Baghdad hospital for special surgery, including 10 non-obese patients with BPH,and 10 overweight or obese patients with BPH. Body mass index (BMI ) was calculated and blood samples were drawn to determine fasting blood glucose (FBG) , total cholesterol, triglycerides, HDL cholesterol , serum leptin , and prostate-specific antigen (PSA).
Results : BMI value ,Triglycerides , and serum leptin was significantly higher in overweight or obese patients ( p ˂ 0.05 ),and there was non significant high level of FBG , PSA , total cholesterol compared to non obese ( p ˃0.05 ). Significant lower level of HDL cholesterol was also noticed inobese patients (p ˂0.5 ). In non obese patients, . PSA correlated negatively with BMI,leptin, triglycerides and FBG, positively with total cholesterol and HDL cholesterol. While inobesepatients , PSA correlated negatively with BMI, leptin, HDL cholesterol,and FBG .PSA correlated positively with total cholesterol and triglycerides .
Conclusion :In this study , obesity marker like serum leptin ,BMI and triglycerides , was significantly higher in overweight/obese BPH patients compared to non obese,but correlated negatively with PSA (except with triglycerides) . Further research exploring relationship of diet, obesity with prostate cancer and BPH will lead to understanding of the complex inter-relationship.